Survival from cancer in teenagers and young adults in England, 1979-2003.

2.50
Hdl Handle:
http://hdl.handle.net/10541/68837
Title:
Survival from cancer in teenagers and young adults in England, 1979-2003.
Authors:
Birch, Jillian M; Pang, Dong; Alston, Robert D; Rowan, Steve; Geraci, Marco; Moran, Anthony; Eden, Tim O B
Abstract:
Cancer is the leading cause of disease-related death in teenagers and young adults aged 13-24 years (TYAs) in England. We have analysed national 5-year relative survival among more than 30,000 incident cancer cases in TYAs. For cancer overall, 5-year survival improved from 63% in 1979-84 to 74% during 1996-2001 (P<0.001). However, there were no sustained improvements in survival over time among high-grade brain tumours and bone and soft tissue sarcomas. Survival patterns varied by age group (13-16, 17-20, 21-24 years), sex and diagnosis. Survival from leukaemia and brain tumours was better in the youngest age group but in the oldest from germ-cell tumours (GCTs). For lymphomas, bone and soft tissue sarcomas, melanoma and carcinomas, survival was not significantly associated with age. Females had a better survival than males except for GCTs. Most groups showed no association between survival and socioeconomic deprivation, but for leukaemias, head and neck carcinoma and colorectal carcinoma, survival was significantly poorer with increasing deprivation. These results will aid the development of national specialised service provision for this age group and identify areas of clinical need that present the greatest challenges.
Affiliation:
Cancer Research UK, Paediatric and Familial Cancer Research Group, University of Manchester, Royal Manchester Children's Hospital, Stancliffe, Hospital Road, Manchester M27 4HA, UK. jillian.birch@manchester.ac.uk
Citation:
Survival from cancer in teenagers and young adults in England, 1979-2003. 2008, 99 (5):830-5 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
2-Sep-2008
URI:
http://hdl.handle.net/10541/68837
DOI:
10.1038/sj.bjc.6604460
PubMed ID:
18728673
Type:
Article
Language:
en
ISSN:
1532-1827
Appears in Collections:
All Christie Publications ; North West Cancer Intelligence Service

Full metadata record

DC FieldValue Language
dc.contributor.authorBirch, Jillian M-
dc.contributor.authorPang, Dong-
dc.contributor.authorAlston, Robert D-
dc.contributor.authorRowan, Steve-
dc.contributor.authorGeraci, Marco-
dc.contributor.authorMoran, Anthony-
dc.contributor.authorEden, Tim O B-
dc.date.accessioned2009-05-22T14:18:46Z-
dc.date.available2009-05-22T14:18:46Z-
dc.date.issued2008-09-02-
dc.identifier.citationSurvival from cancer in teenagers and young adults in England, 1979-2003. 2008, 99 (5):830-5 Br. J. Canceren
dc.identifier.issn1532-1827-
dc.identifier.pmid18728673-
dc.identifier.doi10.1038/sj.bjc.6604460-
dc.identifier.urihttp://hdl.handle.net/10541/68837-
dc.description.abstractCancer is the leading cause of disease-related death in teenagers and young adults aged 13-24 years (TYAs) in England. We have analysed national 5-year relative survival among more than 30,000 incident cancer cases in TYAs. For cancer overall, 5-year survival improved from 63% in 1979-84 to 74% during 1996-2001 (P<0.001). However, there were no sustained improvements in survival over time among high-grade brain tumours and bone and soft tissue sarcomas. Survival patterns varied by age group (13-16, 17-20, 21-24 years), sex and diagnosis. Survival from leukaemia and brain tumours was better in the youngest age group but in the oldest from germ-cell tumours (GCTs). For lymphomas, bone and soft tissue sarcomas, melanoma and carcinomas, survival was not significantly associated with age. Females had a better survival than males except for GCTs. Most groups showed no association between survival and socioeconomic deprivation, but for leukaemias, head and neck carcinoma and colorectal carcinoma, survival was significantly poorer with increasing deprivation. These results will aid the development of national specialised service provision for this age group and identify areas of clinical need that present the greatest challenges.en
dc.language.isoenen
dc.subjectCancer Classificationen
dc.subjectCanceren
dc.subjectTrendsen
dc.subjectNational Cancer Statisticsen
dc.subjectSocioeconomic Deprivationen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshEngland-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshSocioeconomic Factors-
dc.subject.meshSurvival Analysis-
dc.titleSurvival from cancer in teenagers and young adults in England, 1979-2003.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK, Paediatric and Familial Cancer Research Group, University of Manchester, Royal Manchester Children's Hospital, Stancliffe, Hospital Road, Manchester M27 4HA, UK. jillian.birch@manchester.ac.uken
dc.identifier.journalBritish Journal of Canceren

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