2.50
Hdl Handle:
http://hdl.handle.net/10541/67990
Title:
Meta-analysis in medical research: potentials and limitations.
Authors:
Zwahlen, Marcel; Renehan, Andrew G; Egger, Matthias
Abstract:
Meta-analysis, the statistical combination of results from several studies to produce a single estimate of a treatment effect or size of an association, continues to attract controversy. We illustrate and discuss the promises and limitations of meta-analysis. Meta-analysis of clinical trials can prevent delays in the introduction of effective treatments or lead to the timely identification of adverse effects. However, meta-analyses are liable to numerous biases, both at the level of the individual study and the selection of studies for inclusion in meta-analysis. The biases and confounding factors that threaten the validity of individual studies will also affect meta-analyses of observational studies. We argue that meta-analyses should only be performed within the framework of systematic reviews that have been prepared using methods that minimize bias and address the combinability of studies.
Affiliation:
Department of Social and Preventive Medicine, University of Berne, Berne, Switzerland. zwahlen@ispm.unibe.ch
Citation:
Meta-analysis in medical research: potentials and limitations., 26 (3):320-9 Urol. Oncol.
Journal:
Urologic Oncology
Issue Date:
12-May-2009
URI:
http://hdl.handle.net/10541/67990
DOI:
10.1016/j.urolonc.2006.12.001
PubMed ID:
18452828
Type:
Article
Language:
en
ISSN:
1078-1439
Appears in Collections:
All Christie Publications ; Surgery

Full metadata record

DC FieldValue Language
dc.contributor.authorZwahlen, Marcel-
dc.contributor.authorRenehan, Andrew G-
dc.contributor.authorEgger, Matthias-
dc.date.accessioned2009-05-12T18:20:45Z-
dc.date.available2009-05-12T18:20:45Z-
dc.date.issued2009-05-12T18:20:45Z-
dc.identifier.citationMeta-analysis in medical research: potentials and limitations., 26 (3):320-9 Urol. Oncol.en
dc.identifier.issn1078-1439-
dc.identifier.pmid18452828-
dc.identifier.doi10.1016/j.urolonc.2006.12.001-
dc.identifier.urihttp://hdl.handle.net/10541/67990-
dc.description.abstractMeta-analysis, the statistical combination of results from several studies to produce a single estimate of a treatment effect or size of an association, continues to attract controversy. We illustrate and discuss the promises and limitations of meta-analysis. Meta-analysis of clinical trials can prevent delays in the introduction of effective treatments or lead to the timely identification of adverse effects. However, meta-analyses are liable to numerous biases, both at the level of the individual study and the selection of studies for inclusion in meta-analysis. The biases and confounding factors that threaten the validity of individual studies will also affect meta-analyses of observational studies. We argue that meta-analyses should only be performed within the framework of systematic reviews that have been prepared using methods that minimize bias and address the combinability of studies.en
dc.language.isoenen
dc.subjectHeterogeityen
dc.subjectMedical Researchen
dc.subject.meshBiomedical Research-
dc.subject.meshControlled Clinical Trials as Topic-
dc.subject.meshHumans-
dc.subject.meshMedical Oncology-
dc.subject.meshMeta-Analysis as Topic-
dc.subject.meshMyocardial Infarction-
dc.subject.meshReview Literature as Topic-
dc.subject.meshUrology-
dc.titleMeta-analysis in medical research: potentials and limitations.en
dc.typeArticleen
dc.contributor.departmentDepartment of Social and Preventive Medicine, University of Berne, Berne, Switzerland. zwahlen@ispm.unibe.chen
dc.identifier.journalUrologic Oncologyen

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