No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/67976
Title:
No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma.
Authors:
Charnley, Natalie; Airley, R; Du Plessis, D; West, Catharine M L; Brock, Cathryn S; Barnett, C; Matthews, Julian C; Symonds, Kirsten; Bottomly, M; Swindell, Ric; Price, Patricia M
Abstract:
The purpose of this study was to compare glucose metabolism, measured using 18F-fluorodeoxyglucose positron emission tomography ([18F]FDG-PET), with the expression of Glut-1 and -3 and hexokinase I (Hex I) and II in high-grade glioma. The retrospective study involved 27 patients with WHO classification grade III and IV glioma, with either newly diagnosed or recurrent tumours. Patients underwent dynamic and static [18F]FDG-PET to glucose metabolic rate (MRGlu) and standardised uptake value (SUV), respectively. Tumour biopsies were obtained and stained using immunohistochemistry for the expression of Glut-1, -3, Hex I and II. Relationships between variables were studied using Spearman's rank correlation test. Results showed that the expression of Glut-1, Glut-3, Hex I and Hex II varied between and within the tumour samples. The mean of MRGlu was 0.2 (range 0.09-0.25) micromol/min/ml and that of SUV was 4.2 (range 3.2-5.2). There were no significant relationships among the tumour expression of any of the proteins studied with either MRGlu or SUV (p>0.21 for all). In conclusion, the lack of relationship between the immunohistochemical expression of Glut-1, -3, Hex I or II and glucose metabolism measured using [18F]FDG-PET in patients with high-grade glioma may be due to the tissue heterogeneity and presence of necrosis in high-grade tumours.
Affiliation:
Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. natalie.charnley@manchester.ac.uk
Citation:
No relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma. 2008, 20 (3):537-42 Oncol. Rep.
Journal:
Oncology Reports
Issue Date:
Sep-2008
URI:
http://hdl.handle.net/10541/67976
PubMed ID:
18695903
Type:
Article
Language:
en
ISSN:
1021-335X
Appears in Collections:
All Christie Publications ; Manchester Molecular Imaging Centre; Academic Department of Radiation Oncology - ADRO

Full metadata record

DC FieldValue Language
dc.contributor.authorCharnley, Natalie-
dc.contributor.authorAirley, R-
dc.contributor.authorDu Plessis, D-
dc.contributor.authorWest, Catharine M L-
dc.contributor.authorBrock, Cathryn S-
dc.contributor.authorBarnett, C-
dc.contributor.authorMatthews, Julian C-
dc.contributor.authorSymonds, Kirsten-
dc.contributor.authorBottomly, M-
dc.contributor.authorSwindell, Ric-
dc.contributor.authorPrice, Patricia M-
dc.date.accessioned2009-05-12T16:47:33Z-
dc.date.available2009-05-12T16:47:33Z-
dc.date.issued2008-09-
dc.identifier.citationNo relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma. 2008, 20 (3):537-42 Oncol. Rep.en
dc.identifier.issn1021-335X-
dc.identifier.pmid18695903-
dc.identifier.urihttp://hdl.handle.net/10541/67976-
dc.description.abstractThe purpose of this study was to compare glucose metabolism, measured using 18F-fluorodeoxyglucose positron emission tomography ([18F]FDG-PET), with the expression of Glut-1 and -3 and hexokinase I (Hex I) and II in high-grade glioma. The retrospective study involved 27 patients with WHO classification grade III and IV glioma, with either newly diagnosed or recurrent tumours. Patients underwent dynamic and static [18F]FDG-PET to glucose metabolic rate (MRGlu) and standardised uptake value (SUV), respectively. Tumour biopsies were obtained and stained using immunohistochemistry for the expression of Glut-1, -3, Hex I and II. Relationships between variables were studied using Spearman's rank correlation test. Results showed that the expression of Glut-1, Glut-3, Hex I and Hex II varied between and within the tumour samples. The mean of MRGlu was 0.2 (range 0.09-0.25) micromol/min/ml and that of SUV was 4.2 (range 3.2-5.2). There were no significant relationships among the tumour expression of any of the proteins studied with either MRGlu or SUV (p>0.21 for all). In conclusion, the lack of relationship between the immunohistochemical expression of Glut-1, -3, Hex I or II and glucose metabolism measured using [18F]FDG-PET in patients with high-grade glioma may be due to the tissue heterogeneity and presence of necrosis in high-grade tumours.en
dc.language.isoenen
dc.subjectGlucose Metabolismen
dc.subjectTumour Markersen
dc.subjectPositron-Emission Tomographyen
dc.subject.meshAstrocytoma-
dc.subject.meshBrain Neoplasms-
dc.subject.meshFluorodeoxyglucose F18-
dc.subject.meshGlucose-
dc.subject.meshGlucose Transporter Type 1-
dc.subject.meshGlucose Transporter Type 3-
dc.subject.meshHexokinase-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshPositron-Emission Tomography-
dc.subject.meshPrognosis-
dc.subject.meshRadiopharmaceuticals-
dc.subject.meshRetrospective Studies-
dc.subject.meshTumor Markers, Biological-
dc.titleNo relationship between 18F-fluorodeoxyglucose positron emission tomography and expression of Glut-1 and -3 and hexokinase I and II in high-grade glioma.en
dc.typeArticleen
dc.contributor.departmentWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK. natalie.charnley@manchester.ac.uken
dc.identifier.journalOncology Reportsen
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.