New insights into the mechanisms of action of radioimmunotherapy in lymphoma.
Affiliation
School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.Issue Date
2008-08
Metadata
Show full item recordAbstract
The exquisite sensitivity of haematological malignancies to targeted radiation alongside the impressive results achieved by the pioneers in this field suggests that radioimmunotherapy is likely to be a productive area for future clinical research. Recent experimental work has demonstrated that the combination of targeted radiation and antibody effector mechanisms are critical to long-term clearance of tumour. This review provides the background of clinical and biological insights into the mechanisms of action of radioimmunotherapy.Citation
New insights into the mechanisms of action of radioimmunotherapy in lymphoma. 2008, 60 (8):987-98 J. Pharm. Pharmacol.Journal
The Journal of Pharmacy and PharmacologyDOI
10.1211/jpp.60.8.0006PubMed ID
18644192Type
ArticleLanguage
enISSN
0022-3573ae974a485f413a2113503eed53cd6c53
10.1211/jpp.60.8.0006
Scopus Count
Related articles
- Impact of nodal regression on radiation dose for lymphoma patients after radioimmunotherapy.
- Authors: Hartmann Siantar CL, DeNardo GL, DeNardo SJ
- Issue date: 2003 Aug
- Microscopic intratumoral dosimetry of radiolabeled antibodies is a critical determinant of successful radioimmunotherapy in B-cell lymphoma.
- Authors: Du Y, Honeychurch J, Glennie M, Johnson P, Illidge T
- Issue date: 2007 Feb 1
- Radioimmunotherapy with alpha-particle emitting radionuclides.
- Authors: Zalutsky MR, Pozzi OR
- Issue date: 2004 Dec
- Pretargeted versus directly targeted radioimmunotherapy combined with anti-CD20 antibody consolidation therapy of non-Hodgkin lymphoma.
- Authors: Sharkey RM, Karacay H, Johnson CR, Litwin S, Rossi EA, McBride WJ, Chang CH, Goldenberg DM
- Issue date: 2009 Mar
- Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma.
- Authors: Dauer LT, St Germain J, Williamson MJ, Zanzonico P, Modak S, Cheung NK, Divgi C
- Issue date: 2007 Jan