Changes in cancer incidence in teenagers and young adults (ages 13 to 24 years) in England 1979-2003.

2.50
Hdl Handle:
http://hdl.handle.net/10541/67934
Title:
Changes in cancer incidence in teenagers and young adults (ages 13 to 24 years) in England 1979-2003.
Authors:
Alston, Robert D; Geraci, Marco; Eden, Tim O B; Moran, Anthony; Rowan, Steve; Birch, Jillian M
Abstract:
BACKGROUND: Cancer for teenagers and young adults represents a major source of morbidity and mortality. Trends in cancer incidence can provide pointers concerning how changes in the environment and in personal behavior affect cancer risks. METHODS: Data on 39,129 neoplasms in individuals ages 13 to 24 years who were diagnosed in England from 1979 to 2003 were analyzed. Variability in incidence by time period and differences in the time trends by age group, sex, and geographic region were analyzed using generalized linear models. RESULTS: Incidence rates of leukemias, lymphomas, central nervous system, bone, and germ cell tumors; melanoma; and carcinomas of the thyroid, ovary, cervix, and colon/rectum increased over time (all P < .01); whereas the incidence of carcinomas of the stomach and bladder decreased (both P < .01). These changes were consistent by age, sex, and region for most neoplasms. Melanoma incidence stabilized in southern England by 1993 but continued to increase in northern England (P = .001). The increase in non-Hodgkin lymphoma was greater in individuals ages 20 to 24 year than in younger individuals, but the increase in Hodgkin lymphoma was confined to individuals ages 13 to 14 years. CONCLUSIONS: The changes in incidence rates may have been caused in part by environmental changes and in part by behavioral changes in young individuals. Some of these results can be used to inform public health campaigns, which can be constructed to encourage better lifestyle choices by young individuals.
Affiliation:
Cancer Research UK Pediatric and Familial Cancer Research Group, Royal Manchester Children's Hospital, University of Manchester, Stancliffe, Manchester, United Kingdom. robert.d.alston@manchester.ac.uk
Citation:
Changes in cancer incidence in teenagers and young adults (ages 13 to 24 years) in England 1979-2003. 2008, 113 (10):2807-15 Cancer
Journal:
Cancer
Issue Date:
15-Nov-2008
URI:
http://hdl.handle.net/10541/67934
DOI:
10.1002/cncr.23901
PubMed ID:
18846564
Type:
Article
Language:
en
ISSN:
0008-543X
Appears in Collections:
All Christie Publications ; North West Cancer Intelligence Service

Full metadata record

DC FieldValue Language
dc.contributor.authorAlston, Robert D-
dc.contributor.authorGeraci, Marco-
dc.contributor.authorEden, Tim O B-
dc.contributor.authorMoran, Anthony-
dc.contributor.authorRowan, Steve-
dc.contributor.authorBirch, Jillian M-
dc.date.accessioned2009-05-12T14:27:58Z-
dc.date.available2009-05-12T14:27:58Z-
dc.date.issued2008-11-15-
dc.identifier.citationChanges in cancer incidence in teenagers and young adults (ages 13 to 24 years) in England 1979-2003. 2008, 113 (10):2807-15 Canceren
dc.identifier.issn0008-543X-
dc.identifier.pmid18846564-
dc.identifier.doi10.1002/cncr.23901-
dc.identifier.urihttp://hdl.handle.net/10541/67934-
dc.description.abstractBACKGROUND: Cancer for teenagers and young adults represents a major source of morbidity and mortality. Trends in cancer incidence can provide pointers concerning how changes in the environment and in personal behavior affect cancer risks. METHODS: Data on 39,129 neoplasms in individuals ages 13 to 24 years who were diagnosed in England from 1979 to 2003 were analyzed. Variability in incidence by time period and differences in the time trends by age group, sex, and geographic region were analyzed using generalized linear models. RESULTS: Incidence rates of leukemias, lymphomas, central nervous system, bone, and germ cell tumors; melanoma; and carcinomas of the thyroid, ovary, cervix, and colon/rectum increased over time (all P < .01); whereas the incidence of carcinomas of the stomach and bladder decreased (both P < .01). These changes were consistent by age, sex, and region for most neoplasms. Melanoma incidence stabilized in southern England by 1993 but continued to increase in northern England (P = .001). The increase in non-Hodgkin lymphoma was greater in individuals ages 20 to 24 year than in younger individuals, but the increase in Hodgkin lymphoma was confined to individuals ages 13 to 14 years. CONCLUSIONS: The changes in incidence rates may have been caused in part by environmental changes and in part by behavioral changes in young individuals. Some of these results can be used to inform public health campaigns, which can be constructed to encourage better lifestyle choices by young individuals.en
dc.language.isoenen
dc.subjectCanceren
dc.subjectEpidemiologyen
dc.subjectMelanomaen
dc.subject.meshAdolescent-
dc.subject.meshAge Distribution-
dc.subject.meshEngland-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.subject.meshYoung Adult-
dc.titleChanges in cancer incidence in teenagers and young adults (ages 13 to 24 years) in England 1979-2003.en
dc.typeArticleen
dc.contributor.departmentCancer Research UK Pediatric and Familial Cancer Research Group, Royal Manchester Children's Hospital, University of Manchester, Stancliffe, Manchester, United Kingdom. robert.d.alston@manchester.ac.uken
dc.identifier.journalCanceren

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