The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine.

2.50
Hdl Handle:
http://hdl.handle.net/10541/66861
Title:
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine.
Authors:
Eyden, Brian P
Abstract:
The phrase translational research' conveys the idea of the pursuit of applications for the treatment of human disease.The myofibroblast, long known for having a role in wound-healing, and for its presence in fibrotic conditions and tumour stroma, is becoming a focus for translational research, not least through its increasingly documented role as a tumour-promoting cell.In fibroproliferative conditions, cancer and tissue engineering, the myofibroblast, derived partly and possibly from circulating bone-marrow-derived cells and epithelial-to-mesenchymal transformation, is attracting great attention.In cancer, this cell was initially regarded as a barrier to tumour dissemination, but there is now a growing body of evidence to indicate that it is an active participant in tumour progression.While the involvement of the myofibroblast in these pathological processes is pushing the myofibroblast into the limelight of translational medicine as a target for potential anti-fibrotic and anti-cancer therapy, there are still numerous indications from the literature that the myofibroblast is a poorly understood cell in terms of its differentiation.Partly, this is due to a failure to appreciate the contribution of electron microscopy to understanding the nature of this cell.This paper, therefore, is devoted to detailing the principal phenotypic characteristics of the myofibroblast and promotes the argument that understanding how the myofibroblast carries out its roles in normal biological and in pathological processes will be enhanced by a sound understanding of its cellular differentiation, which in turn arguably demands a significant ultrastructural input.
Affiliation:
Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, UK. brian.eyden@christine.nhs.uk
Citation:
The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine., 12 (1):22-37 J. Cell. Mol. Med.
Journal:
Journal of Cellular and Molecular Medicine
Issue Date:
1-May-2009
URI:
http://hdl.handle.net/10541/66861
DOI:
10.1111/j.1582-4934.2007.00213.x
PubMed ID:
18182061
Type:
Article
Language:
en
ISSN:
1582-1838
Appears in Collections:
All Christie Publications ; Pathology

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian P-
dc.date.accessioned2009-05-01T10:37:15Z-
dc.date.available2009-05-01T10:37:15Z-
dc.date.issued2009-05-01T10:37:15Z-
dc.identifier.citationThe myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine., 12 (1):22-37 J. Cell. Mol. Med.en
dc.identifier.issn1582-1838-
dc.identifier.pmid18182061-
dc.identifier.doi10.1111/j.1582-4934.2007.00213.x-
dc.identifier.urihttp://hdl.handle.net/10541/66861-
dc.description.abstractThe phrase translational research' conveys the idea of the pursuit of applications for the treatment of human disease.The myofibroblast, long known for having a role in wound-healing, and for its presence in fibrotic conditions and tumour stroma, is becoming a focus for translational research, not least through its increasingly documented role as a tumour-promoting cell.In fibroproliferative conditions, cancer and tissue engineering, the myofibroblast, derived partly and possibly from circulating bone-marrow-derived cells and epithelial-to-mesenchymal transformation, is attracting great attention.In cancer, this cell was initially regarded as a barrier to tumour dissemination, but there is now a growing body of evidence to indicate that it is an active participant in tumour progression.While the involvement of the myofibroblast in these pathological processes is pushing the myofibroblast into the limelight of translational medicine as a target for potential anti-fibrotic and anti-cancer therapy, there are still numerous indications from the literature that the myofibroblast is a poorly understood cell in terms of its differentiation.Partly, this is due to a failure to appreciate the contribution of electron microscopy to understanding the nature of this cell.This paper, therefore, is devoted to detailing the principal phenotypic characteristics of the myofibroblast and promotes the argument that understanding how the myofibroblast carries out its roles in normal biological and in pathological processes will be enhanced by a sound understanding of its cellular differentiation, which in turn arguably demands a significant ultrastructural input.en
dc.language.isoenen
dc.subjectMyofibroblasten
dc.subjectCanceren
dc.subjectTumour Stromaen
dc.subjectUltrastructureen
dc.subjectTherapyen
dc.subject.meshAnimals-
dc.subject.meshCell Differentiation-
dc.subject.meshFibroblasts-
dc.subject.meshFibrosis-
dc.subject.meshHumans-
dc.subject.meshMyocytes, Smooth Muscle-
dc.subject.meshNeoplasms-
dc.subject.meshPericytes-
dc.subject.meshPhenotype-
dc.subject.meshWound Healing-
dc.titleThe myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, UK. brian.eyden@christine.nhs.uken
dc.identifier.journalJournal of Cellular and Molecular Medicineen

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