2.50
Hdl Handle:
http://hdl.handle.net/10541/66859
Title:
The myofibroblast and its tumours.
Authors:
Eyden, Brian P; Banerjee, Saumitra S; Shenjere, Patrick; Fisher, C
Abstract:
Tumours and tumour-like lesions of myofibroblasts may present diagnostic difficulty because of their rarity and because of uncertainties in identifying the myofibroblast. The objectives of this review are to provide a definition of the myofibroblast and an account of its biology for facilitating an understanding of the cell and of myofibroblastic lesions; and to describe, in the context of common diagnostic problems, the features of benign and malignant myofibroblastic lesions. The main characteristics of the myofibroblast include a spindled or stellate morphology; immunostaining for alpha-smooth muscle actin and the extra domain A variant of cellular fibronectin; and an ultrastructure of rough endoplasmic reticulum, peripheral contractile filaments and the cell-to-matrix junction known as the fibronexus. On this basis, lesions traditionally regarded as myofibroblastic are shown to vary in their level of differentiation, and some appear to be smooth muscle rather than myofibroblastic. Immunohistochemistry and electron microscopy, used together, are emphasised as being important for maximum diagnostic confidence in some myofibroblastic lesions.
Affiliation:
Department of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, UK. brian.eyden@christie.nhs.uk
Citation:
The myofibroblast and its tumours. 2009, 62 (3):236-49 J. Clin. Pathol.
Journal:
Journal of Clinical Pathology
Issue Date:
Mar-2009
URI:
http://hdl.handle.net/10541/66859
DOI:
10.1136/jcp.2008.061630
PubMed ID:
18930983
Type:
Article
Language:
en
ISSN:
1472-4146
Appears in Collections:
All Christie Publications ; Pathology

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian P-
dc.contributor.authorBanerjee, Saumitra S-
dc.contributor.authorShenjere, Patrick-
dc.contributor.authorFisher, C-
dc.date.accessioned2009-05-01T10:31:45Z-
dc.date.available2009-05-01T10:31:45Z-
dc.date.issued2009-03-
dc.identifier.citationThe myofibroblast and its tumours. 2009, 62 (3):236-49 J. Clin. Pathol.en
dc.identifier.issn1472-4146-
dc.identifier.pmid18930983-
dc.identifier.doi10.1136/jcp.2008.061630-
dc.identifier.urihttp://hdl.handle.net/10541/66859-
dc.description.abstractTumours and tumour-like lesions of myofibroblasts may present diagnostic difficulty because of their rarity and because of uncertainties in identifying the myofibroblast. The objectives of this review are to provide a definition of the myofibroblast and an account of its biology for facilitating an understanding of the cell and of myofibroblastic lesions; and to describe, in the context of common diagnostic problems, the features of benign and malignant myofibroblastic lesions. The main characteristics of the myofibroblast include a spindled or stellate morphology; immunostaining for alpha-smooth muscle actin and the extra domain A variant of cellular fibronectin; and an ultrastructure of rough endoplasmic reticulum, peripheral contractile filaments and the cell-to-matrix junction known as the fibronexus. On this basis, lesions traditionally regarded as myofibroblastic are shown to vary in their level of differentiation, and some appear to be smooth muscle rather than myofibroblastic. Immunohistochemistry and electron microscopy, used together, are emphasised as being important for maximum diagnostic confidence in some myofibroblastic lesions.en
dc.language.isoenen
dc.subjectTumouren
dc.subjectMyofibroblasten
dc.subjectMyofibrolastic Lesionsen
dc.titleThe myofibroblast and its tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Foundation Trust, Manchester, UK. brian.eyden@christie.nhs.uken
dc.identifier.journalJournal of Clinical Pathologyen
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