2.50
Hdl Handle:
http://hdl.handle.net/10541/66858
Title:
Pax genes in embryogenesis and oncogenesis.
Authors:
Wang, Qiuyu; Fang, Wen-Hui; Krupinski, Jerzy; Kumar, Shant; Slevin, Mark; Kumar, Patricia
Abstract:
The paired box genes are a family of nine developmental control genes, which in human beings (PAX) and mice (Pax) encode nuclear transcription factors. The temporal and spatial expressions of these highly conserved genes are tightly regulated during foetal development including organogenesis. PAX/Pax genes are switched off during the terminal differentiation of most structures. Specific mutations within a number of PAX/Pax genes lead to developmental abnormalities in both human beings and mice. Mutation in PAX3 causes Waardenburg syndrome, and craniofacial-deafness-hand syndrome. The Splotch phenotype in mouse exhibits defects in neural crest derivatives such as, pigment cells, sympathetic ganglia and cardiac neural crest-derived structures. The PAX family also plays key roles in several human malignancies. In particular, PAX3 is involved in rhabdomyosarcoma and tumours of neural crest origin, including melanoma and neuroblastoma. This review critically evaluates the roles of PAX/Pax in oncogenesis. It especially highlights recent advances in knowledge of how their genetic alterations directly interfere in the transcriptional networks that regulate cell differentiation, proliferation, migration and survival and may contribute to oncogenesis.
Affiliation:
School of Biology, Chemistry and Health Science, Manchester Metropolitan University, and Department of Pathology Sciences, Christie Hospital, Manchester, United Kingdom.
Citation:
Pax genes in embryogenesis and oncogenesis. 2008, 12 (6A):2281-94 J. Cell. Mol. Med.
Journal:
Journal of Cellular and Molecular Medicine
Issue Date:
Dec-2008
URI:
http://hdl.handle.net/10541/66858
DOI:
10.1111/j.1582-4934.2008.00427.x
PubMed ID:
18627422
Type:
Article
Language:
en
ISSN:
1582-1838
Appears in Collections:
All Christie Publications ; Pathology

Full metadata record

DC FieldValue Language
dc.contributor.authorWang, Qiuyu-
dc.contributor.authorFang, Wen-Hui-
dc.contributor.authorKrupinski, Jerzy-
dc.contributor.authorKumar, Shant-
dc.contributor.authorSlevin, Mark-
dc.contributor.authorKumar, Patricia-
dc.date.accessioned2009-05-01T10:30:50Z-
dc.date.available2009-05-01T10:30:50Z-
dc.date.issued2008-12-
dc.identifier.citationPax genes in embryogenesis and oncogenesis. 2008, 12 (6A):2281-94 J. Cell. Mol. Med.en
dc.identifier.issn1582-1838-
dc.identifier.pmid18627422-
dc.identifier.doi10.1111/j.1582-4934.2008.00427.x-
dc.identifier.urihttp://hdl.handle.net/10541/66858-
dc.description.abstractThe paired box genes are a family of nine developmental control genes, which in human beings (PAX) and mice (Pax) encode nuclear transcription factors. The temporal and spatial expressions of these highly conserved genes are tightly regulated during foetal development including organogenesis. PAX/Pax genes are switched off during the terminal differentiation of most structures. Specific mutations within a number of PAX/Pax genes lead to developmental abnormalities in both human beings and mice. Mutation in PAX3 causes Waardenburg syndrome, and craniofacial-deafness-hand syndrome. The Splotch phenotype in mouse exhibits defects in neural crest derivatives such as, pigment cells, sympathetic ganglia and cardiac neural crest-derived structures. The PAX family also plays key roles in several human malignancies. In particular, PAX3 is involved in rhabdomyosarcoma and tumours of neural crest origin, including melanoma and neuroblastoma. This review critically evaluates the roles of PAX/Pax in oncogenesis. It especially highlights recent advances in knowledge of how their genetic alterations directly interfere in the transcriptional networks that regulate cell differentiation, proliferation, migration and survival and may contribute to oncogenesis.en
dc.language.isoenen
dc.subjectTranscription Factorsen
dc.subjectPAXen
dc.subjectOncogenesisen
dc.subjectEmbryogenesisen
dc.subject.meshAlternative Splicing-
dc.subject.meshAnimals-
dc.subject.meshEmbryonic Development-
dc.subject.meshGene Therapy-
dc.subject.meshHumans-
dc.subject.meshMelanocytes-
dc.subject.meshMelanoma-
dc.subject.meshMice-
dc.subject.meshModels, Genetic-
dc.subject.meshMuscle Development-
dc.subject.meshNeoplasms-
dc.subject.meshNeuroblastoma-
dc.subject.meshNeurogenesis-
dc.subject.meshOncogenes-
dc.subject.meshPaired Box Transcription Factors-
dc.subject.meshRhabdomyosarcoma-
dc.titlePax genes in embryogenesis and oncogenesis.en
dc.typeArticleen
dc.contributor.departmentSchool of Biology, Chemistry and Health Science, Manchester Metropolitan University, and Department of Pathology Sciences, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalJournal of Cellular and Molecular Medicineen

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