The role of endothelial progenitor cells in tumour vasculogenesis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/66857
Title:
The role of endothelial progenitor cells in tumour vasculogenesis.
Authors:
Ding, Yi-tao; Kumar, Shant; Yu, De-cai
Abstract:
OBJECTIVE: To review the biological behaviour of endothelial progenitor cells and their role and significance in tumour vasculogenesis. DATA SOURCES: The data in this review were mainly from Medline and PubMed for the relevant articles in English published from March, 1997, to March, 2008. The search terms were 'endothelial progenitor cells' (EPCs) and 'neoplasm'. Articles about the biological behaviour of EPCs and their roles in tumour vasculogenesis were included. RESULTS: EPCs, whose characteristics are similar to those of endothelial cells (ECs) and stem cells, contribute to tumour vasculogenesis during tumour progression. The mobilisation, recruitment, homing and incorporation of EPCs into tumours are multi-step and multi-factor events during tumour vasculogenesis. This complex process requires the participation of many growth factors and cells, such as tumour cells, ECs, stromal cells and EPCs in the tumour microenvironment. However, there is still some debate about EPC distribution, contribution, origin and differentiation in tumour vasculogenesis. CONCLUSIONS: The characterisation of tumour-associated EPCs may provide valuable clues for more specific anti-angiogenesis therapy and/or tumour diagnosis. Many challenges remain in understanding definition, differentiation, mobilisation and recruitment of EPCs.
Affiliation:
Institute of Hepatobiliary Surgery, Nanjing University, Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, China. drdingyitao@sina.com.cn
Citation:
The role of endothelial progenitor cells in tumour vasculogenesis. 2008, 75 (5):265-73 Pathobiology
Journal:
Pathobiology
Issue Date:
2008
URI:
http://hdl.handle.net/10541/66857
DOI:
10.1159/000151706
PubMed ID:
18931528
Type:
Article
Language:
en
ISSN:
1423-0291
Appears in Collections:
All Christie Publications ; Pathology

Full metadata record

DC FieldValue Language
dc.contributor.authorDing, Yi-tao-
dc.contributor.authorKumar, Shant-
dc.contributor.authorYu, De-cai-
dc.date.accessioned2009-05-01T10:29:54Z-
dc.date.available2009-05-01T10:29:54Z-
dc.date.issued2008-
dc.identifier.citationThe role of endothelial progenitor cells in tumour vasculogenesis. 2008, 75 (5):265-73 Pathobiologyen
dc.identifier.issn1423-0291-
dc.identifier.pmid18931528-
dc.identifier.doi10.1159/000151706-
dc.identifier.urihttp://hdl.handle.net/10541/66857-
dc.description.abstractOBJECTIVE: To review the biological behaviour of endothelial progenitor cells and their role and significance in tumour vasculogenesis. DATA SOURCES: The data in this review were mainly from Medline and PubMed for the relevant articles in English published from March, 1997, to March, 2008. The search terms were 'endothelial progenitor cells' (EPCs) and 'neoplasm'. Articles about the biological behaviour of EPCs and their roles in tumour vasculogenesis were included. RESULTS: EPCs, whose characteristics are similar to those of endothelial cells (ECs) and stem cells, contribute to tumour vasculogenesis during tumour progression. The mobilisation, recruitment, homing and incorporation of EPCs into tumours are multi-step and multi-factor events during tumour vasculogenesis. This complex process requires the participation of many growth factors and cells, such as tumour cells, ECs, stromal cells and EPCs in the tumour microenvironment. However, there is still some debate about EPC distribution, contribution, origin and differentiation in tumour vasculogenesis. CONCLUSIONS: The characterisation of tumour-associated EPCs may provide valuable clues for more specific anti-angiogenesis therapy and/or tumour diagnosis. Many challenges remain in understanding definition, differentiation, mobilisation and recruitment of EPCs.en
dc.language.isoenen
dc.subjectAngiogenesisen
dc.subjectCanceren
dc.subjectTargeted Therapyen
dc.subjectTumour Vasculatureen
dc.subjectVasculogenesisen
dc.subject.meshAnimals-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshHumans-
dc.subject.meshNeoplasms-
dc.subject.meshNeovascularization, Pathologic-
dc.subject.meshStem Cells-
dc.titleThe role of endothelial progenitor cells in tumour vasculogenesis.en
dc.typeArticleen
dc.contributor.departmentInstitute of Hepatobiliary Surgery, Nanjing University, Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, China. drdingyitao@sina.com.cnen
dc.identifier.journalPathobiologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.