Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/66174
Title:
Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy.
Authors:
Elkord, Eyad; Hawkins, Robert E; Stern, Peter L
Abstract:
BACKGROUND: Despite improvement in conventional strategies for treating gastrointestinal (GI) carcinoma, large numbers of patients still suffer from incurable or progressive disease. OBJECTIVE: Here we consider the prospects for circumventing limitations and maximising the efficacy of different immunotherapies. Methods: We summarise different cancer vaccines and targeted drugs and highlight the scientific rationale of using immunotherapy for targeting GI cancers, in addition to the potential strategies for improving immunotherapeutic efficacy. RESULTS/CONCLUSION: Many cancer vaccines and antibody-directed therapies have been tested in early phase clinical trials and demonstrated proof of concept and safety. As yet few have been properly evaluated for clinical efficacy; although adoptive transfer of tumour-associated-antigen-specific T cells has shown dramatic clinical responses in some patients. The recognition of a role for T regulatory cells in limiting anti-tumour immunity has provided momentum for developing strategies to over-ride such immunoinhibitory effects. There is some evidence that conventional therapies may work by influencing these negative factors and allowing expression of immune control mechanisms. An important developing area for clinical evaluation is the testing of combined conventional and immunotherapeutic modalities which may provide for synergy; thereby circumventing the limitations of individualised treatments and generating additional clinical benefits.
Affiliation:
University of Manchester, Paterson Institute for Cancer Research, Department of Medical Oncology, Wilmslow Road, Manchester M20 4BX, UK. eelkord@picr.man.ac.uk
Citation:
Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy. 2008, 8 (4):385-95 Expert Opin Biol Ther
Journal:
Expert Opinion on Biological Therapy
Issue Date:
Apr-2008
URI:
http://hdl.handle.net/10541/66174
DOI:
10.1517/14712598.8.4.385
PubMed ID:
18352844
Type:
Article
Language:
en
ISSN:
1744-7682
Appears in Collections:
All Paterson Institute for Cancer Research; Medical Oncology

Full metadata record

DC FieldValue Language
dc.contributor.authorElkord, Eyad-
dc.contributor.authorHawkins, Robert E-
dc.contributor.authorStern, Peter L-
dc.date.accessioned2009-04-24T09:21:34Z-
dc.date.available2009-04-24T09:21:34Z-
dc.date.issued2008-04-
dc.identifier.citationImmunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy. 2008, 8 (4):385-95 Expert Opin Biol Theren
dc.identifier.issn1744-7682-
dc.identifier.pmid18352844-
dc.identifier.doi10.1517/14712598.8.4.385-
dc.identifier.urihttp://hdl.handle.net/10541/66174-
dc.description.abstractBACKGROUND: Despite improvement in conventional strategies for treating gastrointestinal (GI) carcinoma, large numbers of patients still suffer from incurable or progressive disease. OBJECTIVE: Here we consider the prospects for circumventing limitations and maximising the efficacy of different immunotherapies. Methods: We summarise different cancer vaccines and targeted drugs and highlight the scientific rationale of using immunotherapy for targeting GI cancers, in addition to the potential strategies for improving immunotherapeutic efficacy. RESULTS/CONCLUSION: Many cancer vaccines and antibody-directed therapies have been tested in early phase clinical trials and demonstrated proof of concept and safety. As yet few have been properly evaluated for clinical efficacy; although adoptive transfer of tumour-associated-antigen-specific T cells has shown dramatic clinical responses in some patients. The recognition of a role for T regulatory cells in limiting anti-tumour immunity has provided momentum for developing strategies to over-ride such immunoinhibitory effects. There is some evidence that conventional therapies may work by influencing these negative factors and allowing expression of immune control mechanisms. An important developing area for clinical evaluation is the testing of combined conventional and immunotherapeutic modalities which may provide for synergy; thereby circumventing the limitations of individualised treatments and generating additional clinical benefits.en
dc.language.isoenen
dc.subjectColorectal Canceren
dc.subjectGastrointestinal Canceren
dc.subjectT Regulatory Cellsen
dc.subjectTumour Escapeen
dc.subject.meshAnimals-
dc.subject.meshAntibodies-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshCancer Vaccines-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshGastrointestinal Neoplasms-
dc.subject.meshHumans-
dc.subject.meshImmunologic Factors-
dc.subject.meshImmunotherapy-
dc.subject.meshImmunotherapy, Adoptive-
dc.subject.meshT-Lymphocytes-
dc.subject.meshTreatment Outcome-
dc.subject.meshTumor Escape-
dc.titleImmunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy.en
dc.typeArticleen
dc.contributor.departmentUniversity of Manchester, Paterson Institute for Cancer Research, Department of Medical Oncology, Wilmslow Road, Manchester M20 4BX, UK. eelkord@picr.man.ac.uken
dc.identifier.journalExpert Opinion on Biological Therapyen

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