GH replacement reduces increased lipid peroxidation in GH-deficient adults.

2.50
Hdl Handle:
http://hdl.handle.net/10541/66075
Title:
GH replacement reduces increased lipid peroxidation in GH-deficient adults.
Authors:
Karbownik-Lewinska, Malgorzata; Kokoszko, Agnieszka; Lewandowski, Krzysztof C; Shalet, Stephen M; Lewinski, Andrzej
Abstract:
BACKGROUND: GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS: To evaluate the extent to which GH replacement might reverse the increased LPO in GH-deficient adults and to analyse if this phenomenon might be involved in the improvement of metabolic disturbances due to GH treatment. Serum concentrations of malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA), as an index of LPO, were measured at baseline, and after 12 and 24 months of GH replacement in 40 adult patients with severe GH deficiency (both in adult- and childhood-onset) and in 40 healthy volunteers, matched for sex, age and body mass index (BMI). Correlations were evaluated between LPO and lipids, IGF-I, metalloproteinase-2 and -9 (MMP-2, -9), vascular endothelial growth factor (VEGF), BMI and GH dose. RESULTS: LPO values in GH-deficient patients were several-fold higher than in controls [55.36 +/- 2.27 vs. 4.19 +/- 0.42 nmol/mg protein (mean +/- SEM), P < 0.0001] and decreased significantly over time with GH replacement to 38.61 +/- 2.15 nmol/mg protein (i.e. by approximately 30%), though still remaining markedly elevated compared with controls (P < 0.0001). The proatherogenic lipid profile parameters correlated positively with LPO in the childhood-onset subgroup before GH replacement. GH replacement restored the positive correlation between LPO and age in male patients (r = 0.57, P = 0.013; r = 0.8, P < 0.001, at 12 and 24 months of GH replacement, respectively). CONCLUSIONS: GH replacement partially reverses the grossly abnormal LPO in GH-deficient adults. It is highly probable, therefore, that oxidative mechanisms are involved in the overall improvement of metabolic changes due to GH replacement.
Affiliation:
Department of Oncological Endocrinology, Medical University, Lodz, Poland.
Citation:
GH replacement reduces increased lipid peroxidation in GH-deficient adults. 2008, 68 (6):957-64 Clin. Endocrinol.
Journal:
Clinical Endocrinology
Issue Date:
Jun-2008
URI:
http://hdl.handle.net/10541/66075
DOI:
10.1111/j.1365-2265.2007.03142.x
PubMed ID:
18031310
Type:
Article
Language:
en
ISSN:
1365-2265
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKarbownik-Lewinska, Malgorzata-
dc.contributor.authorKokoszko, Agnieszka-
dc.contributor.authorLewandowski, Krzysztof C-
dc.contributor.authorShalet, Stephen M-
dc.contributor.authorLewinski, Andrzej-
dc.date.accessioned2009-04-23T15:58:32Z-
dc.date.available2009-04-23T15:58:32Z-
dc.date.issued2008-06-
dc.identifier.citationGH replacement reduces increased lipid peroxidation in GH-deficient adults. 2008, 68 (6):957-64 Clin. Endocrinol.en
dc.identifier.issn1365-2265-
dc.identifier.pmid18031310-
dc.identifier.doi10.1111/j.1365-2265.2007.03142.x-
dc.identifier.urihttp://hdl.handle.net/10541/66075-
dc.description.abstractBACKGROUND: GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS: To evaluate the extent to which GH replacement might reverse the increased LPO in GH-deficient adults and to analyse if this phenomenon might be involved in the improvement of metabolic disturbances due to GH treatment. Serum concentrations of malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA), as an index of LPO, were measured at baseline, and after 12 and 24 months of GH replacement in 40 adult patients with severe GH deficiency (both in adult- and childhood-onset) and in 40 healthy volunteers, matched for sex, age and body mass index (BMI). Correlations were evaluated between LPO and lipids, IGF-I, metalloproteinase-2 and -9 (MMP-2, -9), vascular endothelial growth factor (VEGF), BMI and GH dose. RESULTS: LPO values in GH-deficient patients were several-fold higher than in controls [55.36 +/- 2.27 vs. 4.19 +/- 0.42 nmol/mg protein (mean +/- SEM), P < 0.0001] and decreased significantly over time with GH replacement to 38.61 +/- 2.15 nmol/mg protein (i.e. by approximately 30%), though still remaining markedly elevated compared with controls (P < 0.0001). The proatherogenic lipid profile parameters correlated positively with LPO in the childhood-onset subgroup before GH replacement. GH replacement restored the positive correlation between LPO and age in male patients (r = 0.57, P = 0.013; r = 0.8, P < 0.001, at 12 and 24 months of GH replacement, respectively). CONCLUSIONS: GH replacement partially reverses the grossly abnormal LPO in GH-deficient adults. It is highly probable, therefore, that oxidative mechanisms are involved in the overall improvement of metabolic changes due to GH replacement.en
dc.language.isoenen
dc.subjectGrowth Hormone Replacementen
dc.subjectAdulten
dc.subjectLipid Peroxidationen
dc.titleGH replacement reduces increased lipid peroxidation in GH-deficient adults.en
dc.typeArticleen
dc.contributor.departmentDepartment of Oncological Endocrinology, Medical University, Lodz, Poland.en
dc.identifier.journalClinical Endocrinologyen

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