Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/65742
Title:
Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy.
Authors:
Nettekoven, Sina; Ströhle, Alexander; Trunz, Birgit; Wolters, Maike; Hoffmann, Susanne; Horn, R; Steinert, Martin; Brabant, Georg E; Lichtinghagen, Ralf; Welkoborsky, Hans-Jürgen; Tuxhorn, Ingrid; Hahn, Andreas
Abstract:
Reports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism associated with antiepileptic drug (AED) treatment are inconsistent and predominantly restricted to adults. In this cross-sectional observational study, the aim was to evaluate the influence of AED treatment on vitamin D status and markers of bone turnover in children with epilepsy. In 38 children taking AEDs and 44 healthy control subjects, blood samples were collected to determine the levels of serum 25-OHD, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), bone alkaline phosphatase (BAP), osteocalcin (OC) and C terminal telopeptide of type I collagen (ICTP). More than 75% of the patients were vitamin D deficient (serum 25-OHD<20 ng/mL) and 21% of the patients had an insufficient vitamin D status (serum 25-OHD=20-30 ng/mL). In the patients, the serum levels of OC (p = 0.002) and BAP (p < 0.001) were significantly increased, but ICTP (p = 0.002) concentrations were significantly decreased compared with the control group. When patients where divided into two groups according to their medication (mono- or polytherapy), significantly lower 25-OHD (p = 0.038) and ICTP (p = 0.005) levels and elevated BAP (p = 0.023) concentrations were found in patients under polytherapy. An association between 25-OHD and the measured bone markers could not be determined. Our results indicate that the prevalence of vitamin D deficiency in epilepsy patients under AED treatment is high, especially under polytherapy, and alteration markers of bone formation and resorption suggests an accelerated skeletal turnover. The routine monitoring of serum 25-OHD and vitamin D supplementation on an individual basis should be considered.
Affiliation:
Nutrition Physiology and Human Nutrition Unit, Institute of Food Science, Leibniz University of Hannover, Wunstorfer Str. 14, 30453, Hannover, Germany. sina.nettekoven@lw.uni-hannover.de
Citation:
Effects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy. 2008, 167 (12):1369-77 Eur. J. Pediatr.
Journal:
European Journal of Pediatrics
Issue Date:
Dec-2008
URI:
http://hdl.handle.net/10541/65742
DOI:
10.1007/s00431-008-0672-7
PubMed ID:
18270736
Type:
Article
Language:
en
ISSN:
1432-1076
Appears in Collections:
All Christie Publications ; Endocrinology

Full metadata record

DC FieldValue Language
dc.contributor.authorNettekoven, Sina-
dc.contributor.authorStröhle, Alexander-
dc.contributor.authorTrunz, Birgit-
dc.contributor.authorWolters, Maike-
dc.contributor.authorHoffmann, Susanne-
dc.contributor.authorHorn, R-
dc.contributor.authorSteinert, Martin-
dc.contributor.authorBrabant, Georg E-
dc.contributor.authorLichtinghagen, Ralf-
dc.contributor.authorWelkoborsky, Hans-Jürgen-
dc.contributor.authorTuxhorn, Ingrid-
dc.contributor.authorHahn, Andreas-
dc.date.accessioned2009-04-21T16:55:33Z-
dc.date.available2009-04-21T16:55:33Z-
dc.date.issued2008-12-
dc.identifier.citationEffects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy. 2008, 167 (12):1369-77 Eur. J. Pediatr.en
dc.identifier.issn1432-1076-
dc.identifier.pmid18270736-
dc.identifier.doi10.1007/s00431-008-0672-7-
dc.identifier.urihttp://hdl.handle.net/10541/65742-
dc.description.abstractReports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism associated with antiepileptic drug (AED) treatment are inconsistent and predominantly restricted to adults. In this cross-sectional observational study, the aim was to evaluate the influence of AED treatment on vitamin D status and markers of bone turnover in children with epilepsy. In 38 children taking AEDs and 44 healthy control subjects, blood samples were collected to determine the levels of serum 25-OHD, intact parathyroid hormone (iPTH), calcium (Ca), phosphate (P), bone alkaline phosphatase (BAP), osteocalcin (OC) and C terminal telopeptide of type I collagen (ICTP). More than 75% of the patients were vitamin D deficient (serum 25-OHD<20 ng/mL) and 21% of the patients had an insufficient vitamin D status (serum 25-OHD=20-30 ng/mL). In the patients, the serum levels of OC (p = 0.002) and BAP (p < 0.001) were significantly increased, but ICTP (p = 0.002) concentrations were significantly decreased compared with the control group. When patients where divided into two groups according to their medication (mono- or polytherapy), significantly lower 25-OHD (p = 0.038) and ICTP (p = 0.005) levels and elevated BAP (p = 0.023) concentrations were found in patients under polytherapy. An association between 25-OHD and the measured bone markers could not be determined. Our results indicate that the prevalence of vitamin D deficiency in epilepsy patients under AED treatment is high, especially under polytherapy, and alteration markers of bone formation and resorption suggests an accelerated skeletal turnover. The routine monitoring of serum 25-OHD and vitamin D supplementation on an individual basis should be considered.en
dc.language.isoenen
dc.subjectBone Turnoveren
dc.subjectAntiepileptic Therapyen
dc.subject.meshAlkaline Phosphatase-
dc.subject.meshAnticonvulsants-
dc.subject.meshBiological Markers-
dc.subject.meshBone Resorption-
dc.subject.meshCalcium-
dc.subject.meshChild-
dc.subject.meshCollagen Type I-
dc.subject.meshCross-Sectional Studies-
dc.subject.meshEpilepsy-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshOsteocalcin-
dc.subject.meshParathyroid Hormone-
dc.subject.meshQuestionnaires-
dc.subject.meshVitamin D-
dc.subject.meshVitamin D Deficiency-
dc.titleEffects of antiepileptic drug therapy on vitamin D status and biochemical markers of bone turnover in children with epilepsy.en
dc.typeArticleen
dc.contributor.departmentNutrition Physiology and Human Nutrition Unit, Institute of Food Science, Leibniz University of Hannover, Wunstorfer Str. 14, 30453, Hannover, Germany. sina.nettekoven@lw.uni-hannover.deen
dc.identifier.journalEuropean Journal of Pediatricsen

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