Significance of blood neutrophil-to-lymphocyte ratio for prognostic stratification of patients with gastroesophageal junction adenocarcinoma in the era of the 8th edition of the American Joint Committee on Cancer (AJCC8) staging.

2.50
Hdl Handle:
http://hdl.handle.net/10541/620402
Title:
Significance of blood neutrophil-to-lymphocyte ratio for prognostic stratification of patients with gastroesophageal junction adenocarcinoma in the era of the 8th edition of the American Joint Committee on Cancer (AJCC8) staging.
Authors:
Conway, Alicia-Marie; Salih, Zena; Papaxoinis, Georgios; Fletcher, Kimberly; Weaver, Jamie M J; Patrao, Ana; Noble, Robert; Stamatopoulou, Sofia; Owen-Holt, Vikki; Mansoor, Was
Abstract:
The prognosis of patients with gastroesophageal junction (GOJ) adenocarcinoma depends mainly on the clinical staging, as described by the new AJCC8 (American Joint Committee on Cancer 8th edition). Evidence suggests that peripheral blood neutrophil-to-lymphocyte ratio (NLR) may be of prognostic significance in patients with upper gastrointestinal cancers. We examined the prognostic significance of NLR in the era of the new AJCC8 staging system. In this single-centre cohort study, retrospective data on patients with operable GOJ adenocarcinoma treated with perioperative chemotherapy were analysed. The prognostic significance of baseline NLR in combination with AJCC8 clinical staging and other patient characteristics was examined for both time-to-progression (TTP) and overall survival (OS). Of 316 patients, 245 (77.5%) underwent radical surgery. Fifty-one patients (16.2%) developed unresectable disease due to early disease progression. NLR was the only baseline factor independently associated with the development of early disease progression. AJCC8 clinical staging was significantly associated with TTP and OS. In addition, NLR ≥ 3 was predictive of poorer TTP (p = 0.001) and OS (p = 0.002), confirmed in multivariate Cox-regression analysis. NLR ≥ 3 was prognostic, especially in patients with clinical stage III for TTP (p = 0.006) and OS (p = 0.025) and in patients with clinical stage IVA for OS (p = 0.017). NLR significantly improved the prognostic classification of patients by different AJCC8 clinical stages, with a c-index improved from 0.554 to 0.592 (p < 0.001). NLR was confirmed to be an independent prognostic factor in this cohort and could be used in combination with AJCC8 clinical staging to improve the baseline prognostic stratification of patients with newly diagnosed resectable GOJ adenocarcinoma.
Affiliation:
The Christie Hospital Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK
Citation:
Significance of blood neutrophil-to-lymphocyte ratio for prognostic stratification of patients with gastroesophageal junction adenocarcinoma in the era of the 8th edition of the American Joint Committee on Cancer (AJCC8) staging. 2017, 34 (6):116 Med Oncol
Journal:
Medical Oncology
Issue Date:
Jun-2017
URI:
http://hdl.handle.net/10541/620402
DOI:
10.1007/s12032-017-0976-4
PubMed ID:
28500616
Type:
Article
Language:
en
ISSN:
1559-131X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorConway, Alicia-Marieen
dc.contributor.authorSalih, Zenaen
dc.contributor.authorPapaxoinis, Georgiosen
dc.contributor.authorFletcher, Kimberlyen
dc.contributor.authorWeaver, Jamie M Jen
dc.contributor.authorPatrao, Anaen
dc.contributor.authorNoble, Roberten
dc.contributor.authorStamatopoulou, Sofiaen
dc.contributor.authorOwen-Holt, Vikkien
dc.contributor.authorMansoor, Wasen
dc.date.accessioned2017-06-29T10:14:48Z-
dc.date.available2017-06-29T10:14:48Z-
dc.date.issued2017-06-
dc.identifier.citationSignificance of blood neutrophil-to-lymphocyte ratio for prognostic stratification of patients with gastroesophageal junction adenocarcinoma in the era of the 8th edition of the American Joint Committee on Cancer (AJCC8) staging. 2017, 34 (6):116 Med Oncolen
dc.identifier.issn1559-131X-
dc.identifier.pmid28500616-
dc.identifier.doi10.1007/s12032-017-0976-4-
dc.identifier.urihttp://hdl.handle.net/10541/620402-
dc.description.abstractThe prognosis of patients with gastroesophageal junction (GOJ) adenocarcinoma depends mainly on the clinical staging, as described by the new AJCC8 (American Joint Committee on Cancer 8th edition). Evidence suggests that peripheral blood neutrophil-to-lymphocyte ratio (NLR) may be of prognostic significance in patients with upper gastrointestinal cancers. We examined the prognostic significance of NLR in the era of the new AJCC8 staging system. In this single-centre cohort study, retrospective data on patients with operable GOJ adenocarcinoma treated with perioperative chemotherapy were analysed. The prognostic significance of baseline NLR in combination with AJCC8 clinical staging and other patient characteristics was examined for both time-to-progression (TTP) and overall survival (OS). Of 316 patients, 245 (77.5%) underwent radical surgery. Fifty-one patients (16.2%) developed unresectable disease due to early disease progression. NLR was the only baseline factor independently associated with the development of early disease progression. AJCC8 clinical staging was significantly associated with TTP and OS. In addition, NLR ≥ 3 was predictive of poorer TTP (p = 0.001) and OS (p = 0.002), confirmed in multivariate Cox-regression analysis. NLR ≥ 3 was prognostic, especially in patients with clinical stage III for TTP (p = 0.006) and OS (p = 0.025) and in patients with clinical stage IVA for OS (p = 0.017). NLR significantly improved the prognostic classification of patients by different AJCC8 clinical stages, with a c-index improved from 0.554 to 0.592 (p < 0.001). NLR was confirmed to be an independent prognostic factor in this cohort and could be used in combination with AJCC8 clinical staging to improve the baseline prognostic stratification of patients with newly diagnosed resectable GOJ adenocarcinoma.en
dc.language.isoenen
dc.rightsArchived with thanks to Medical oncology (Northwood, London, England)en
dc.titleSignificance of blood neutrophil-to-lymphocyte ratio for prognostic stratification of patients with gastroesophageal junction adenocarcinoma in the era of the 8th edition of the American Joint Committee on Cancer (AJCC8) staging.en
dc.typeArticleen
dc.contributor.departmentThe Christie Hospital Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UKen
dc.identifier.journalMedical Oncologyen

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