CD30-positive T-cell lymphoproliferative disorder of the oral mucosa--an indolent lesion: report of 4 cases.

2.50
Hdl Handle:
http://hdl.handle.net/10541/58693
Title:
CD30-positive T-cell lymphoproliferative disorder of the oral mucosa--an indolent lesion: report of 4 cases.
Authors:
Agarwal, Monica; Shenjere, Patrick; Blewitt, Robert W; Hall, Gillian; Sloan, Philip; Pigadas, N; Banerjee, Saumitra S
Abstract:
Four cases of CD30-positive T-cell lymphoproliferative disorder (CD30+ LPD) of the oral mucosa are described. This article aims to draw attention to this entity and to emphasize its usual benign clinical behavior despite its resemblance to T-cell lymphoma. All the patients were adults. Three of the lesions were on the dorsal surface of the tongue and 1 affected the buccal mucosa. All biopsies showed a dense lymphoid infiltrate composed of CD30+ atypical T cells with a polymorphous infiltrate in the background, which included eosinophils. In 1 case, monoclonal T-cell expansion was detected by molecular techniques. Three cases tested for Epstein-Barr virus were all negative. It is concluded that primary CD30+ T-cell LPD of the oral mucosa can be regarded as the oral counterpart of cutaneous CD30+ LPD such as lymphomatoid papulosis or anaplastic large cell lymphoma. Recognition of the condition is important to avoid overtreatment.
Affiliation:
University Hospitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom.
Citation:
CD30-positive T-cell lymphoproliferative disorder of the oral mucosa--an indolent lesion: report of 4 cases. 2008, 16 (3):286-90 Int. J. Surg. Pathol.
Journal:
International Journal of Surgical Pathology
Issue Date:
Jul-2008
URI:
http://hdl.handle.net/10541/58693
DOI:
10.1177/1066896907313755
PubMed ID:
18387994
Type:
Article
Language:
en
ISSN:
1066-8969
Appears in Collections:
All Christie Publications ; Pathology

Full metadata record

DC FieldValue Language
dc.contributor.authorAgarwal, Monica-
dc.contributor.authorShenjere, Patrick-
dc.contributor.authorBlewitt, Robert W-
dc.contributor.authorHall, Gillian-
dc.contributor.authorSloan, Philip-
dc.contributor.authorPigadas, N-
dc.contributor.authorBanerjee, Saumitra S-
dc.date.accessioned2009-04-01T22:58:09Z-
dc.date.available2009-04-01T22:58:09Z-
dc.date.issued2008-07-
dc.identifier.citationCD30-positive T-cell lymphoproliferative disorder of the oral mucosa--an indolent lesion: report of 4 cases. 2008, 16 (3):286-90 Int. J. Surg. Pathol.en
dc.identifier.issn1066-8969-
dc.identifier.pmid18387994-
dc.identifier.doi10.1177/1066896907313755-
dc.identifier.urihttp://hdl.handle.net/10541/58693-
dc.description.abstractFour cases of CD30-positive T-cell lymphoproliferative disorder (CD30+ LPD) of the oral mucosa are described. This article aims to draw attention to this entity and to emphasize its usual benign clinical behavior despite its resemblance to T-cell lymphoma. All the patients were adults. Three of the lesions were on the dorsal surface of the tongue and 1 affected the buccal mucosa. All biopsies showed a dense lymphoid infiltrate composed of CD30+ atypical T cells with a polymorphous infiltrate in the background, which included eosinophils. In 1 case, monoclonal T-cell expansion was detected by molecular techniques. Three cases tested for Epstein-Barr virus were all negative. It is concluded that primary CD30+ T-cell LPD of the oral mucosa can be regarded as the oral counterpart of cutaneous CD30+ LPD such as lymphomatoid papulosis or anaplastic large cell lymphoma. Recognition of the condition is important to avoid overtreatment.en
dc.language.isoenen
dc.subjectOral Mucosaen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAntigens, CD30-
dc.subject.meshFemale-
dc.subject.meshGene Rearrangement, T-Lymphocyte-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymphoproliferative Disorders-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMouth Mucosa-
dc.subject.meshRemission, Spontaneous-
dc.subject.meshT-Lymphocytes-
dc.subject.meshTongue-
dc.titleCD30-positive T-cell lymphoproliferative disorder of the oral mucosa--an indolent lesion: report of 4 cases.en
dc.typeArticleen
dc.contributor.departmentUniversity Hospitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom.en
dc.identifier.journalInternational Journal of Surgical Pathologyen

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