Predictive factors for failure to identify sentinel nodes in head and neck squamous cell carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/58688
Title:
Predictive factors for failure to identify sentinel nodes in head and neck squamous cell carcinoma.
Authors:
Hornstra, Marije T; Alkureishi, Lee W T; Ross, Gary L; Shoaib, Taimur; Soutar, David S
Abstract:
BACKGROUND: The aim of this study was to ascertain which factors determine success of sentinel node biopsy (SNB). METHODS: We conducted a retrospective review of 121 patients with head and neck squamous cell carcinoma undergoing SNB to stage the neck. All patients underwent the triple-diagnostic procedure of preoperative lymphoscintigraphy, intraoperative blue dye, and a gamma probe. Factors contributing to failure of SNB were identified. RESULTS: SNB was unsuccessful in 12 of 121 patients (10%). Seven of the 12 patients had cT1/cT2 tumors, and 6 of these were located in the floor of mouth. SN identification was more likely to be successful in patients with cN0 necks, but this did not reach statistical significance (92% vs 84%, p = .268). Factors associated with failure included T classification (p = .01), tumor site (p = .05), and negative preoperative lymphoscintigraphy (p = .0174). CONCLUSION: Successful sentinel lymph node harvest is related to primary tumor site, T classification, and the presence of nodes on preoperative lymphoscintigraphy.
Affiliation:
Plastic Surgery Unit, Canniesburn Hospital, Glasgow Royal Infirmary, Glasgow, United Kingdom.
Citation:
Predictive factors for failure to identify sentinel nodes in head and neck squamous cell carcinoma. 2008, 30 (7):858-62 Head Neck
Journal:
Head & Neck
Issue Date:
Jul-2008
URI:
http://hdl.handle.net/10541/58688
DOI:
10.1002/hed.20787
PubMed ID:
18302276
Type:
Article
Language:
en
ISSN:
1097-0347
Appears in Collections:
All Christie Publications ; Surgery

Full metadata record

DC FieldValue Language
dc.contributor.authorHornstra, Marije T-
dc.contributor.authorAlkureishi, Lee W T-
dc.contributor.authorRoss, Gary L-
dc.contributor.authorShoaib, Taimur-
dc.contributor.authorSoutar, David S-
dc.date.accessioned2009-04-01T23:13:37Z-
dc.date.available2009-04-01T23:13:37Z-
dc.date.issued2008-07-
dc.identifier.citationPredictive factors for failure to identify sentinel nodes in head and neck squamous cell carcinoma. 2008, 30 (7):858-62 Head Necken
dc.identifier.issn1097-0347-
dc.identifier.pmid18302276-
dc.identifier.doi10.1002/hed.20787-
dc.identifier.urihttp://hdl.handle.net/10541/58688-
dc.description.abstractBACKGROUND: The aim of this study was to ascertain which factors determine success of sentinel node biopsy (SNB). METHODS: We conducted a retrospective review of 121 patients with head and neck squamous cell carcinoma undergoing SNB to stage the neck. All patients underwent the triple-diagnostic procedure of preoperative lymphoscintigraphy, intraoperative blue dye, and a gamma probe. Factors contributing to failure of SNB were identified. RESULTS: SNB was unsuccessful in 12 of 121 patients (10%). Seven of the 12 patients had cT1/cT2 tumors, and 6 of these were located in the floor of mouth. SN identification was more likely to be successful in patients with cN0 necks, but this did not reach statistical significance (92% vs 84%, p = .268). Factors associated with failure included T classification (p = .01), tumor site (p = .05), and negative preoperative lymphoscintigraphy (p = .0174). CONCLUSION: Successful sentinel lymph node harvest is related to primary tumor site, T classification, and the presence of nodes on preoperative lymphoscintigraphy.en
dc.language.isoenen
dc.subjectSquamous Cellen
dc.subjectHead and Neck Canceren
dc.subjectMouth Canceren
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshChi-Square Distribution-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshLymph Nodes-
dc.subject.meshLymphatic Metastasis-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshPreoperative Care-
dc.subject.meshProbability-
dc.subject.meshRetrospective Studies-
dc.subject.meshRisk Assessment-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshSentinel Lymph Node Biopsy-
dc.subject.meshSurvival Analysis-
dc.subject.meshTreatment Failure-
dc.subject.meshTreatment Outcome-
dc.titlePredictive factors for failure to identify sentinel nodes in head and neck squamous cell carcinoma.en
dc.typeArticleen
dc.contributor.departmentPlastic Surgery Unit, Canniesburn Hospital, Glasgow Royal Infirmary, Glasgow, United Kingdom.en
dc.identifier.journalHead & Necken

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