Childhood leukaemia: long-term excess mortality and the proportion 'cured'.

2.50
Hdl Handle:
http://hdl.handle.net/10541/58685
Title:
Childhood leukaemia: long-term excess mortality and the proportion 'cured'.
Authors:
Shah, A; Stiller, C A; Kenward, M G; Vincent, T; Eden, Tim O B; Coleman, M P
Abstract:
Survival from childhood leukaemia has increased, but the proportion of children cured is unknown. The proportion 'cured' is defined as the proportion of survivors for whom, as a group, there is no longer excess mortality compared to the general population. Average time to cure is defined as the time since diagnosis at which the excess mortality rate has declined to or below a predetermined small value. Data on children diagnosed with leukaemia during 1971-2000 in Great Britain were used to estimate trends in survival, the proportion cured and the average time to cure. Five-year survival for all types of leukaemia combined rose from 33 to 79% by 2000. The percentage cured rose from 25 to 68% by 1995; it is predicted to increase to 73% for those diagnosed more recently. Average time to cure increased from 12 years (95% confidence interval (CI): 11-14) to 19 years (95% CI: 14-26) for lymphoid leukaemia (average annual increase of 0.3 years; P<0.001), but remained at about 5 years for acute nonlymphoblastic leukaemia. The proportion of children cured of leukaemia has risen dramatically, but the period of excess mortality associated with lymphoid leukaemia has also increased, possibly because of late relapse, secondary malignancy and toxicity from treatment.
Affiliation:
Non-communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. anjali.shah@lshtm.ac.uk
Citation:
Childhood leukaemia: long-term excess mortality and the proportion 'cured'. 2008, 99 (1):219-23 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
8-Jul-2008
URI:
http://hdl.handle.net/10541/58685
DOI:
10.1038/sj.bjc.6604466
PubMed ID:
18594545
Type:
Article
Language:
en
ISSN:
1532-1827
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorShah, A-
dc.contributor.authorStiller, C A-
dc.contributor.authorKenward, M G-
dc.contributor.authorVincent, T-
dc.contributor.authorEden, Tim O B-
dc.contributor.authorColeman, M P-
dc.date.accessioned2009-04-01T23:10:55Z-
dc.date.available2009-04-01T23:10:55Z-
dc.date.issued2008-07-08-
dc.identifier.citationChildhood leukaemia: long-term excess mortality and the proportion 'cured'. 2008, 99 (1):219-23 Br. J. Canceren
dc.identifier.issn1532-1827-
dc.identifier.pmid18594545-
dc.identifier.doi10.1038/sj.bjc.6604466-
dc.identifier.urihttp://hdl.handle.net/10541/58685-
dc.description.abstractSurvival from childhood leukaemia has increased, but the proportion of children cured is unknown. The proportion 'cured' is defined as the proportion of survivors for whom, as a group, there is no longer excess mortality compared to the general population. Average time to cure is defined as the time since diagnosis at which the excess mortality rate has declined to or below a predetermined small value. Data on children diagnosed with leukaemia during 1971-2000 in Great Britain were used to estimate trends in survival, the proportion cured and the average time to cure. Five-year survival for all types of leukaemia combined rose from 33 to 79% by 2000. The percentage cured rose from 25 to 68% by 1995; it is predicted to increase to 73% for those diagnosed more recently. Average time to cure increased from 12 years (95% confidence interval (CI): 11-14) to 19 years (95% CI: 14-26) for lymphoid leukaemia (average annual increase of 0.3 years; P<0.001), but remained at about 5 years for acute nonlymphoblastic leukaemia. The proportion of children cured of leukaemia has risen dramatically, but the period of excess mortality associated with lymphoid leukaemia has also increased, possibly because of late relapse, secondary malignancy and toxicity from treatment.en
dc.language.isoenen
dc.subjectSurvivalen
dc.subjectLeukaemiaen
dc.subject.meshChild-
dc.subject.meshGreat Britain-
dc.subject.meshHumans-
dc.subject.meshLeukemia-
dc.subject.meshRegistries-
dc.subject.meshTime Factors-
dc.titleChildhood leukaemia: long-term excess mortality and the proportion 'cured'.en
dc.typeArticleen
dc.contributor.departmentNon-communicable Disease Epidemiology Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. anjali.shah@lshtm.ac.uken
dc.identifier.journalBritish Journal of Canceren

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