2.50
Hdl Handle:
http://hdl.handle.net/10541/58683
Title:
Divergent differentiation in malignant melanomas: a review.
Authors:
Banerjee, Saumitra S; Eyden, Brian P
Abstract:
The aim of this review was to document and discuss diagnostic problems associated with divergent differentiation ('metaplastic change') in malignant melanomas, defined as the development in these tumours of morphologically, immunohistochemically and/or ultrastructurally recognizable non-melanocytic cell or tissue components. Types of divergent differentiation reported in malignant melanoma include: fibroblastic/myofibroblastic, Schwannian and perineurial, smooth muscle, rhabdomyosarcomatous, osteocartilaginous, ganglionic and ganglioneuroblastic, neuroendocrine and probable epithelial. Divergent differentiation is certainly a rare phenomenon and, when it occurs, can be missed by unwary pathologists and lead to diagnostic uncertainty. A carefully chosen immunohistochemical panel and the input of electron microscopy can help to clarify the nature of the cellular differentiation of these tumours and lead to a correct final diagnosis. The clinical significance of such aberrations is uncertain, nor are the underlying mechanisms as yet well defined.
Affiliation:
Christie Hospital NHS Foundation Trust, Manchester, UK.
Citation:
Divergent differentiation in malignant melanomas: a review. 2008, 52 (2):119-29 Histopathology
Journal:
Histopathology
Issue Date:
Jan-2008
URI:
http://hdl.handle.net/10541/58683
DOI:
10.1111/j.1365-2559.2007.02823.x
PubMed ID:
17825057
Type:
Article
Language:
en
ISSN:
1365-2559
Appears in Collections:
All Christie Publications ; Pathology

Full metadata record

DC FieldValue Language
dc.contributor.authorBanerjee, Saumitra S-
dc.contributor.authorEyden, Brian P-
dc.date.accessioned2009-04-01T23:08:04Z-
dc.date.available2009-04-01T23:08:04Z-
dc.date.issued2008-01-
dc.identifier.citationDivergent differentiation in malignant melanomas: a review. 2008, 52 (2):119-29 Histopathologyen
dc.identifier.issn1365-2559-
dc.identifier.pmid17825057-
dc.identifier.doi10.1111/j.1365-2559.2007.02823.x-
dc.identifier.urihttp://hdl.handle.net/10541/58683-
dc.description.abstractThe aim of this review was to document and discuss diagnostic problems associated with divergent differentiation ('metaplastic change') in malignant melanomas, defined as the development in these tumours of morphologically, immunohistochemically and/or ultrastructurally recognizable non-melanocytic cell or tissue components. Types of divergent differentiation reported in malignant melanoma include: fibroblastic/myofibroblastic, Schwannian and perineurial, smooth muscle, rhabdomyosarcomatous, osteocartilaginous, ganglionic and ganglioneuroblastic, neuroendocrine and probable epithelial. Divergent differentiation is certainly a rare phenomenon and, when it occurs, can be missed by unwary pathologists and lead to diagnostic uncertainty. A carefully chosen immunohistochemical panel and the input of electron microscopy can help to clarify the nature of the cellular differentiation of these tumours and lead to a correct final diagnosis. The clinical significance of such aberrations is uncertain, nor are the underlying mechanisms as yet well defined.en
dc.language.isoenen
dc.subjectElectron Microscopyen
dc.subjectImmunohistochemistryen
dc.subjectMalignant Melanomaen
dc.subjectSkin Canceren
dc.subject.meshCell Differentiation-
dc.subject.meshFibroblasts-
dc.subject.meshGanglion Cysts-
dc.subject.meshHumans-
dc.subject.meshMelanoma-
dc.subject.meshMyocytes, Smooth Muscle-
dc.subject.meshSchwann Cells-
dc.subject.meshSkin Neoplasms-
dc.titleDivergent differentiation in malignant melanomas: a review.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital NHS Foundation Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.