The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial.

2.50
Hdl Handle:
http://hdl.handle.net/10541/58676
Title:
The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial.
Authors:
Kitchener, Henry C; Fletcher, I; Roberts, Caleb; Wheeler, P; Almonte, M; Maguire, Peter
Abstract:
The purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20-64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State-Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening.
Affiliation:
Division of Human Development, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, United Kingdom. henry.kitchener@cmmc.nhs.uk
Citation:
The psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial., 18 (4):743-8 Int. J. Gynecol. Cancer
Journal:
International Journal of Gynecological Cancer
Issue Date:
1-Apr-2009
URI:
http://hdl.handle.net/10541/58676
DOI:
10.1111/j.1525-1438.2007.01113.x
PubMed ID:
17944916
Type:
Article
Language:
en
ISSN:
1525-1438
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorKitchener, Henry C-
dc.contributor.authorFletcher, I-
dc.contributor.authorRoberts, Caleb-
dc.contributor.authorWheeler, P-
dc.contributor.authorAlmonte, M-
dc.contributor.authorMaguire, Peter-
dc.date.accessioned2009-04-01T22:53:34Z-
dc.date.available2009-04-01T22:53:34Z-
dc.date.issued2009-04-01T22:53:34Z-
dc.identifier.citationThe psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial., 18 (4):743-8 Int. J. Gynecol. Canceren
dc.identifier.issn1525-1438-
dc.identifier.pmid17944916-
dc.identifier.doi10.1111/j.1525-1438.2007.01113.x-
dc.identifier.urihttp://hdl.handle.net/10541/58676-
dc.description.abstractThe purpose of the study was to assess the psychosocial impact of human papillomavirus (HPV) testing as an adjunct to cytology in routine primary cervical screening. A controlled study of the psychosocial impact of HPV testing within a randomized trial of HPV testing to assess its efficacy in cervical screening was carried out. The trial provides a randomized setting of revealed HPV results versus concealed results permitting valid comparisons for assessing true psychosocial impact. The setting comprised a large number of general practices in primary care. Women aged 20-64 years who underwent routine cervical screening participated in the study. The intervention was a revealed high-risk HPV test result in addition to cervical cytology. The main outcome was measured using General Health Questionnaire (GHQ-28), Spielberger State-Trait Anxiety Inventory, and Sexual Rating Scale (SRS). Among women with either mildly abnormal or normal cytology, receiving an HPV(+ve) result did not impact significantly on GHQ caseness and mean scores or on Spielberger State and Trait scores when compared with women in whom the HPV(+ve) test result was concealed. Among women with normal cytology, receiving an HPV(+ve) result was associated with a reduction in the Sexual Rating Scale compared with similar women whose HPV(+ve) result was concealed. HPV testing does not add significant psychologic distress when combined with cytology in routine primary cervical screening.en
dc.language.isoenen
dc.subjectHuman Papillomavirusen
dc.subjectCervical Screeningen
dc.subjectHPVen
dc.subject.meshAdult-
dc.subject.meshAlphapapillomavirus-
dc.subject.meshCervical Intraepithelial Neoplasia-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMass Screening-
dc.subject.meshMiddle Aged-
dc.subject.meshPapillomavirus Infections-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshPrognosis-
dc.subject.meshQuestionnaires-
dc.subject.meshRandomized Controlled Trials as Topic-
dc.subject.meshUterine Cervical Neoplasms-
dc.subject.meshVaginal Smears-
dc.titleThe psychosocial impact of human papillomavirus testing in primary cervical screening-a study within a randomized trial.en
dc.typeArticleen
dc.contributor.departmentDivision of Human Development, Academic Unit of Obstetrics and Gynaecology, University of Manchester, Manchester, United Kingdom. henry.kitchener@cmmc.nhs.uken
dc.identifier.journalInternational Journal of Gynecological Canceren

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