2.50
Hdl Handle:
http://hdl.handle.net/10541/56015
Title:
Mitochondrial dynamics and apoptosis: a painful separation.
Authors:
James, Dominic I; Martinou, Jean-Claude
Abstract:
Reporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined.
Affiliation:
Clinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
Citation:
Mitochondrial dynamics and apoptosis: a painful separation. 2008, 15 (3):341-3 Dev. Cell
Journal:
Developmental Cell
Issue Date:
Sep-2008
URI:
http://hdl.handle.net/10541/56015
DOI:
10.1016/j.devcel.2008.08.011
PubMed ID:
18804432
Type:
Article
Language:
en
ISSN:
1534-5807
Appears in Collections:
All Paterson Institute for Cancer Research; Clinical and Experimental Pharmacology Group

Full metadata record

DC FieldValue Language
dc.contributor.authorJames, Dominic I-
dc.contributor.authorMartinou, Jean-Claude-
dc.date.accessioned2009-03-17T16:55:59Z-
dc.date.available2009-03-17T16:55:59Z-
dc.date.issued2008-09-
dc.identifier.citationMitochondrial dynamics and apoptosis: a painful separation. 2008, 15 (3):341-3 Dev. Cellen
dc.identifier.issn1534-5807-
dc.identifier.pmid18804432-
dc.identifier.doi10.1016/j.devcel.2008.08.011-
dc.identifier.urihttp://hdl.handle.net/10541/56015-
dc.description.abstractReporting in Molecular Cell, Sheridan et al. (2008) and Breckenridge et al. (2008) show that mitochondrial fragmentation is not required to induce cell death. Meanwhile, Yamaguchi et al. show that proapoptotic Bcl-2 family members promote cytochrome c mobilization through Opa1-mediated cristae remodeling. Therefore, the connection between mitochondrial structure and apoptosis is more complex than previously imagined.en
dc.language.isoenen
dc.subjectApoptosisen
dc.subjectMitochondrial Structureen
dc.subject.meshAnimals-
dc.subject.meshApoptosis-
dc.subject.meshCytochromes c-
dc.subject.meshCytoskeletal Proteins-
dc.subject.meshMitochondria-
dc.subject.meshMitochondrial Proteins-
dc.subject.meshProto-Oncogene Proteins c-bcl-2-
dc.titleMitochondrial dynamics and apoptosis: a painful separation.en
dc.typeArticleen
dc.contributor.departmentClinical and Experimental Pharmacology, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.en
dc.identifier.journalDevelopmental Cellen

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