The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe.

2.50
Hdl Handle:
http://hdl.handle.net/10541/55826
Title:
The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe.
Authors:
Hagan, Iain M
Abstract:
Commitment to mitosis is regulated by a conserved protein kinase complex called MPF (mitosis-promoting factor). MPF activation triggers a positive-feedback loop that further promotes the activity of its activating phosphatase Cdc25 and is assumed to down-regulate the MPF-inhibitory kinase Wee1. Four protein kinases contribute to this amplification loop: MPF itself, Polo kinase, MAPK (mitogen-activated protein kinase) and Greatwall kinase. The fission yeast SPB (spindle pole body) component Cut12 plays a critical role in modulating mitotic commitment. In this review, I discuss the relationship between Cut12 and the fission yeast Polo kinase Plo1 in mitotic control. These results indicate that commitment to mitosis is co-ordinated by control networks on the spindle pole. I then describe how the Cut12/Plo1 control network links growth control signalling from TOR (target of rapamycin) and MAPK networks to the activation of MPF to regulate the timing of cell division.
Affiliation:
CRUK (Cancer Research UK) Cell Division Laboratory, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. ihagan@picr.man.ac.uk
Citation:
The spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe. 2008, 36 (Pt 5):1097-101 Biochem. Soc. Trans.
Journal:
Biochemical Society Transactions
Issue Date:
Oct-2008
URI:
http://hdl.handle.net/10541/55826
DOI:
10.1042/BST0361097
PubMed ID:
18793196
Type:
Article
Language:
en
ISSN:
0300-5127
Appears in Collections:
All Paterson Institute for Cancer Research; Cell Division

Full metadata record

DC FieldValue Language
dc.contributor.authorHagan, Iain M-
dc.date.accessioned2009-03-16T17:33:02Z-
dc.date.available2009-03-16T17:33:02Z-
dc.date.issued2008-10-
dc.identifier.citationThe spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe. 2008, 36 (Pt 5):1097-101 Biochem. Soc. Trans.en
dc.identifier.issn0300-5127-
dc.identifier.pmid18793196-
dc.identifier.doi10.1042/BST0361097-
dc.identifier.urihttp://hdl.handle.net/10541/55826-
dc.description.abstractCommitment to mitosis is regulated by a conserved protein kinase complex called MPF (mitosis-promoting factor). MPF activation triggers a positive-feedback loop that further promotes the activity of its activating phosphatase Cdc25 and is assumed to down-regulate the MPF-inhibitory kinase Wee1. Four protein kinases contribute to this amplification loop: MPF itself, Polo kinase, MAPK (mitogen-activated protein kinase) and Greatwall kinase. The fission yeast SPB (spindle pole body) component Cut12 plays a critical role in modulating mitotic commitment. In this review, I discuss the relationship between Cut12 and the fission yeast Polo kinase Plo1 in mitotic control. These results indicate that commitment to mitosis is co-ordinated by control networks on the spindle pole. I then describe how the Cut12/Plo1 control network links growth control signalling from TOR (target of rapamycin) and MAPK networks to the activation of MPF to regulate the timing of cell division.en
dc.language.isoenen
dc.subjectMAPKen
dc.subjectMitosis-Promoting Factoren
dc.subjectMPFen
dc.subjectYeastsen
dc.subject.meshEnzyme Activation-
dc.subject.meshMaturation-Promoting Factor-
dc.subject.meshMicrotubule-Associated Proteins-
dc.subject.meshMitogen-Activated Protein Kinases-
dc.subject.meshMitosis-
dc.subject.meshMitotic Spindle Apparatus-
dc.subject.meshPhosphoproteins-
dc.subject.meshProtein Kinases-
dc.subject.meshProtein-Serine-Threonine Kinases-
dc.subject.meshSchizosaccharomyces-
dc.subject.meshSchizosaccharomyces Pombe Proteins-
dc.subject.meshSignal Transduction-
dc.titleThe spindle pole body plays a key role in controlling mitotic commitment in the fission yeast Schizosaccharomyces pombe.en
dc.typeArticleen
dc.contributor.departmentCRUK (Cancer Research UK) Cell Division Laboratory, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. ihagan@picr.man.ac.uken
dc.identifier.journalBiochemical Society Transactionsen

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