2.50
Hdl Handle:
http://hdl.handle.net/10541/55825
Title:
Novel therapeutic strategies by regulatory T cells in allergy.
Authors:
Elkord, Eyad
Abstract:
Natural CD4+CD25+FoxP3+ regulatory T cells (Treg) actively suppress physiological and pathological responses, therefore playing a critical role in controlling peripheral tolerance to self antigens and maintaining immune homeostasis. In normal individuals, natural Treg and interleukin- 10-secreting Treg are able to suppress Th2 responses to allergens, whereas lower levels of Treg or defect in their functionality have been described as potential mechanisms for inducing allergic diseases. In animal models, adoptive transfer of CD4+CD25+Treg has been shown as a promising strategy for preventing or treating allergic disorders. Recent studies show that induction of Treg activity is associated with suppression of allergic responses in allergic patients treated with specific immunotherapy. Herein, I review the potential of Treg as exciting targets for developing new immunotherapeutic strategies for treating allergic diseases.
Affiliation:
Immunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. eelkord@picr.man.ac.uk
Citation:
Novel therapeutic strategies by regulatory T cells in allergy. 2008, 94:150-7 Chem Immunol Allergy
Journal:
Chemical Immunology and Allergy
Issue Date:
2008
URI:
http://hdl.handle.net/10541/55825
DOI:
10.1159/000154999
PubMed ID:
18802345
Type:
Article
Language:
en
ISSN:
1660-2242
Appears in Collections:
All Paterson Institute for Cancer Research; Immunology

Full metadata record

DC FieldValue Language
dc.contributor.authorElkord, Eyad-
dc.date.accessioned2009-03-16T17:29:13Z-
dc.date.available2009-03-16T17:29:13Z-
dc.date.issued2008-
dc.identifier.citationNovel therapeutic strategies by regulatory T cells in allergy. 2008, 94:150-7 Chem Immunol Allergyen
dc.identifier.issn1660-2242-
dc.identifier.pmid18802345-
dc.identifier.doi10.1159/000154999-
dc.identifier.urihttp://hdl.handle.net/10541/55825-
dc.description.abstractNatural CD4+CD25+FoxP3+ regulatory T cells (Treg) actively suppress physiological and pathological responses, therefore playing a critical role in controlling peripheral tolerance to self antigens and maintaining immune homeostasis. In normal individuals, natural Treg and interleukin- 10-secreting Treg are able to suppress Th2 responses to allergens, whereas lower levels of Treg or defect in their functionality have been described as potential mechanisms for inducing allergic diseases. In animal models, adoptive transfer of CD4+CD25+Treg has been shown as a promising strategy for preventing or treating allergic disorders. Recent studies show that induction of Treg activity is associated with suppression of allergic responses in allergic patients treated with specific immunotherapy. Herein, I review the potential of Treg as exciting targets for developing new immunotherapeutic strategies for treating allergic diseases.en
dc.language.isoenen
dc.subjectRegulatory T Cellsen
dc.subjectTregen
dc.subjectAllergyen
dc.titleNovel therapeutic strategies by regulatory T cells in allergy.en
dc.typeArticleen
dc.contributor.departmentImmunology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK. eelkord@picr.man.ac.uken
dc.identifier.journalChemical Immunology and Allergyen

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