Clinical and Experimental Pharmacology Group29

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• Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.
  Tennant, D A; Frezza, C; MacKenzie, E D; Nguyen, Q D; Zheng, L; Selak, M A; Roberts, Darren L; Dive, Caroline; Watson, D G; Aboagye, E O; Gottlieb, E
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  9Feb2010
• Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study.
  Board, Ruth E; Ellison, G; Orr, M C M; Kemsley, K R; McWalter, G; Blockley, L Y; Dearden, S P; Morris, C; Ranson, Malcolm R; Cantarini, M V; Dive, Caroline; Hughes, A
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  8Feb2010
• A small molecule inhibitor of XIAP induces apoptosis and synergises with vinorelbine and cisplatin in NSCLC.
  Dean, Emma J; Ward, Timothy H; Pinilla, C; Houghten, R; Welsh, K; Makin, Guy W J; Ranson, Malcolm R; Dive, Caroline
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  9Dec2009
• Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.
  Roberts, Darren L; Williams, Kaye J; Cowen, Rachel L; Barathova, M; Eustace, A J; Brittain-Dissont, S; Tilby, Michael J; Pearson, D Graham; Ottley, Christopher J; Stratford, Ian J; Dive, Caroline
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  8Dec2009
• Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours.
  Hussein, Deema; Holt, Sarah V; Brookes, K E; Klymenko, T; Adamski, J K; Hogg, Alison; Estlin, E J; Ward, Timothy H; Dive, Caroline; Makin, Guy W J
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  8Dec2009