2.50
Hdl Handle:
http://hdl.handle.net/10541/55035
Title:
Novel cytotoxic drugs: old challenges, new solutions.
Authors:
Ismael, Gustavo F V; Rosa, Daniela D; Mano, Max S; Awada, Ahmad
Abstract:
The discovery of cytotoxic agents was revolutionary for anticancer therapy in the last century, improving survival rates and the quality of life of patients with different types of tumours. However, the development of agents that combine efficacy, safety and convenience remains a great challenge, due to the narrow therapeutic index of some drugs, the fact that they may damage not only cancer cells, but also normal and healthy tissue and the occurrence of resistance, limiting anticancer efficacy. Novel cytotoxic agents have brought certain advantages over the conventional ones, such as shorter administration time, mechanisms to overcome drug resistance and lower incidence of adverse events. In this review we highlight the development of promising novel cytotoxic drugs that will hopefully offer not only gains in efficacy, but also in safety, tolerability and convenience in the treatment of patients with cancer.
Affiliation:
Department of Medical Oncology, Jules Bordet Institute, Université Libre de Bruxelles, Belgium.
Citation:
Novel cytotoxic drugs: old challenges, new solutions. 2008, 34 (1):81-91 Cancer Treat. Rev.
Journal:
Cancer Treatment Reviews
Issue Date:
Feb-2008
URI:
http://hdl.handle.net/10541/55035
DOI:
10.1016/j.ctrv.2007.08.001
PubMed ID:
17905518
Type:
Article
Language:
en
ISSN:
0305-7372
Appears in Collections:
All Paterson Institute for Cancer Research; Medical Oncology

Full metadata record

DC FieldValue Language
dc.contributor.authorIsmael, Gustavo F V-
dc.contributor.authorRosa, Daniela D-
dc.contributor.authorMano, Max S-
dc.contributor.authorAwada, Ahmad-
dc.date.accessioned2009-03-12T17:07:08Z-
dc.date.available2009-03-12T17:07:08Z-
dc.date.issued2008-02-
dc.identifier.citationNovel cytotoxic drugs: old challenges, new solutions. 2008, 34 (1):81-91 Cancer Treat. Rev.en
dc.identifier.issn0305-7372-
dc.identifier.pmid17905518-
dc.identifier.doi10.1016/j.ctrv.2007.08.001-
dc.identifier.urihttp://hdl.handle.net/10541/55035-
dc.description.abstractThe discovery of cytotoxic agents was revolutionary for anticancer therapy in the last century, improving survival rates and the quality of life of patients with different types of tumours. However, the development of agents that combine efficacy, safety and convenience remains a great challenge, due to the narrow therapeutic index of some drugs, the fact that they may damage not only cancer cells, but also normal and healthy tissue and the occurrence of resistance, limiting anticancer efficacy. Novel cytotoxic agents have brought certain advantages over the conventional ones, such as shorter administration time, mechanisms to overcome drug resistance and lower incidence of adverse events. In this review we highlight the development of promising novel cytotoxic drugs that will hopefully offer not only gains in efficacy, but also in safety, tolerability and convenience in the treatment of patients with cancer.en
dc.language.isoenen
dc.subjectCytotoxic Drugsen
dc.subjectCytotoxic Agentsen
dc.subjectCancer-
dc.subject.meshAlbumins-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshDrug Design-
dc.subject.meshDrug Resistance, Neoplasm-
dc.subject.meshEpothilones-
dc.subject.meshHumans-
dc.subject.meshModels, Biological-
dc.subject.meshNeoplasms-
dc.subject.meshPaclitaxel-
dc.subject.meshTaxoids-
dc.titleNovel cytotoxic drugs: old challenges, new solutions.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medical Oncology, Jules Bordet Institute, Université Libre de Bruxelles, Belgium.en
dc.identifier.journalCancer Treatment Reviewsen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.