2.50
Hdl Handle:
http://hdl.handle.net/10541/55034
Title:
Chronic mucocutaneous candidiasis and oesophageal cancer.
Authors:
Rosa, Daniela D; Pasqualotto, Alessandro C; Denning, David W
Abstract:
Chronic mucocutaneous candidiasis (CMC) is often accompanied by endocrine or inflammatory disorders. The association of CMC with squamous cell carcinoma of the oral cavity or oesophagus have been described in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). We describe three cases of CMC and oesophageal cancer without the APECED syndrome. The first case refers to a 41-year-old man with Candida paronychia and oral infection and selective IgA deficiency since childhood, who later developed an oesophageal cancer. The second case is a 30-year-old man who presented CMC features at the age of 2 together with selective IgA deficiency. Later on he was diagnosed with an oesophageal squamous cell carcinoma. His mother, the third case reported, had oral thrush since childhood and at the age of 29 she presented with an oesophageal squamous cell carcinoma. The three patients reported died due to oesophageal cancer. This is the first case report describing the development of oesophageal cancer in patients with CMC without the APECED syndrome. Patients with CMC need close follow-up with good oral hygiene and aggressive treatment of oral and oesophageal candidiasis. Routine endoscopic screening for patients with CMC that develop symptoms of oesophageal candidiasis and for patients with CMC with a family history of oesophageal cancer is suggested. Avoidance of additional risk factors for oral and oesophageal cancer like cigarette smoking and excessive alcohol consumption are also warranted.
Affiliation:
Paterson Institute for Cancer Research, Cancer Research UK, Manchester.
Citation:
Chronic mucocutaneous candidiasis and oesophageal cancer. 2008, 46 (1):85-91 Med. Mycol.
Journal:
Medical Mycology
Issue Date:
Feb-2008
URI:
http://hdl.handle.net/10541/55034
DOI:
10.1080/13693780701616023
PubMed ID:
17852718
Type:
Article
Language:
en
ISSN:
1369-3786
Appears in Collections:
All Paterson Institute for Cancer Research; Medical Oncology

Full metadata record

DC FieldValue Language
dc.contributor.authorRosa, Daniela D-
dc.contributor.authorPasqualotto, Alessandro C-
dc.contributor.authorDenning, David W-
dc.date.accessioned2009-03-12T17:05:54Z-
dc.date.available2009-03-12T17:05:54Z-
dc.date.issued2008-02-
dc.identifier.citationChronic mucocutaneous candidiasis and oesophageal cancer. 2008, 46 (1):85-91 Med. Mycol.en
dc.identifier.issn1369-3786-
dc.identifier.pmid17852718-
dc.identifier.doi10.1080/13693780701616023-
dc.identifier.urihttp://hdl.handle.net/10541/55034-
dc.description.abstractChronic mucocutaneous candidiasis (CMC) is often accompanied by endocrine or inflammatory disorders. The association of CMC with squamous cell carcinoma of the oral cavity or oesophagus have been described in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). We describe three cases of CMC and oesophageal cancer without the APECED syndrome. The first case refers to a 41-year-old man with Candida paronychia and oral infection and selective IgA deficiency since childhood, who later developed an oesophageal cancer. The second case is a 30-year-old man who presented CMC features at the age of 2 together with selective IgA deficiency. Later on he was diagnosed with an oesophageal squamous cell carcinoma. His mother, the third case reported, had oral thrush since childhood and at the age of 29 she presented with an oesophageal squamous cell carcinoma. The three patients reported died due to oesophageal cancer. This is the first case report describing the development of oesophageal cancer in patients with CMC without the APECED syndrome. Patients with CMC need close follow-up with good oral hygiene and aggressive treatment of oral and oesophageal candidiasis. Routine endoscopic screening for patients with CMC that develop symptoms of oesophageal candidiasis and for patients with CMC with a family history of oesophageal cancer is suggested. Avoidance of additional risk factors for oral and oesophageal cancer like cigarette smoking and excessive alcohol consumption are also warranted.en
dc.language.isoenen
dc.subjectMucocutaneous Candidiasisen
dc.subjectOesophageal Canceren
dc.subject.meshAdult-
dc.subject.meshCandidiasis, Chronic Mucocutaneous-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshFatal Outcome-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIgA Deficiency-
dc.subject.meshMale-
dc.subject.meshPolyendocrinopathies, Autoimmune-
dc.subject.meshRisk Factors-
dc.titleChronic mucocutaneous candidiasis and oesophageal cancer.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Cancer Research UK, Manchester.en
dc.identifier.journalMedical Mycologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.