Cribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior.

2.50
Hdl Handle:
http://hdl.handle.net/10541/54014
Title:
Cribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior.
Authors:
Cameselle-Teijeiro, José; Menasce, Lia P; Yap, Beng K; Colaco, Rovel J; Castro, Patricia; Celestino, Ricardo; Ruíz-Ponte, Clara; Soares, Paula; Sobrinho-Simões, Manuel
Abstract:
We describe an especially aggressive case of cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) in a 42-year-old man with familial adenomatous polyposis who died with lung and brain metastases 17 months after thyroidectomy. The angioinvasive neoplasm combined a mixture of trabecular, solid, cribriform, and follicular patterns of growth with CD10+ morules. Follicles were devoid of colloid, and the nuclear features typical of PTC were present in some areas and missing in others. Tumor cells were positive for thyroid transcription factor-1 and, in 40% of the tumoral mass, also were positive for chromogranin and synaptophysin and were negative for thyroglobulin and calcitonin. Strong nuclear staining for beta-catenin was found in all tumor cells, as was positivity for p53 and cyclin D1. In addition to the germline heterozygous APC Ex 2-3 duplication mutation, a somatic homozygous silent p. Thr1493Thr gene variant was found in the neoplastic cells along with RET/PTC rearrangement. This tumor represents the first case of C-MV of PTC showing neuroendocrine differentiation.
Affiliation:
Department of Pathology, Clinical University Hospital, Galician Health Service, University of Santiago de Compostela, Santiago de Compostela, Spain.
Citation:
Cribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior. 2009, 131 (1):134-42 Am. J. Clin. Pathol.
Journal:
American Journal of Clinical Pathology
Issue Date:
Jan-2009
URI:
http://hdl.handle.net/10541/54014
DOI:
10.1309/AJCP7ULS0VSISBEB
PubMed ID:
19095577
Type:
Article
Language:
en
ISSN:
1943-7722
Appears in Collections:
All Christie Publications ; Pathology ; Clinical Oncology

Full metadata record

DC FieldValue Language
dc.contributor.authorCameselle-Teijeiro, José-
dc.contributor.authorMenasce, Lia P-
dc.contributor.authorYap, Beng K-
dc.contributor.authorColaco, Rovel J-
dc.contributor.authorCastro, Patricia-
dc.contributor.authorCelestino, Ricardo-
dc.contributor.authorRuíz-Ponte, Clara-
dc.contributor.authorSoares, Paula-
dc.contributor.authorSobrinho-Simões, Manuel-
dc.date.accessioned2009-03-11T09:33:50Z-
dc.date.available2009-03-11T09:33:50Z-
dc.date.issued2009-01-
dc.identifier.citationCribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior. 2009, 131 (1):134-42 Am. J. Clin. Pathol.en
dc.identifier.issn1943-7722-
dc.identifier.pmid19095577-
dc.identifier.doi10.1309/AJCP7ULS0VSISBEB-
dc.identifier.urihttp://hdl.handle.net/10541/54014-
dc.description.abstractWe describe an especially aggressive case of cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) in a 42-year-old man with familial adenomatous polyposis who died with lung and brain metastases 17 months after thyroidectomy. The angioinvasive neoplasm combined a mixture of trabecular, solid, cribriform, and follicular patterns of growth with CD10+ morules. Follicles were devoid of colloid, and the nuclear features typical of PTC were present in some areas and missing in others. Tumor cells were positive for thyroid transcription factor-1 and, in 40% of the tumoral mass, also were positive for chromogranin and synaptophysin and were negative for thyroglobulin and calcitonin. Strong nuclear staining for beta-catenin was found in all tumor cells, as was positivity for p53 and cyclin D1. In addition to the germline heterozygous APC Ex 2-3 duplication mutation, a somatic homozygous silent p. Thr1493Thr gene variant was found in the neoplastic cells along with RET/PTC rearrangement. This tumor represents the first case of C-MV of PTC showing neuroendocrine differentiation.en
dc.language.isoenen
dc.subjectThyroid Carcinomaen
dc.subjectCribriform-Morular Varianten
dc.subjectPapillary Thyroid Carcinomaen
dc.subjectThyroid Canceren
dc.subjectThyroid Canceren
dc.subject.meshAdenocarcinoma-
dc.subject.meshAdenomatous Polyposis Coli-
dc.subject.meshAdult-
dc.subject.meshBrain Neoplasms-
dc.subject.meshCarcinoma, Papillary-
dc.subject.meshFatal Outcome-
dc.subject.meshHumans-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshThyroid Neoplasms-
dc.titleCribriform-morular variant of papillary thyroid carcinoma: molecular characterization of a case with neuroendocrine differentiation and aggressive behavior.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Clinical University Hospital, Galician Health Service, University of Santiago de Compostela, Santiago de Compostela, Spain.en
dc.identifier.journalAmerican Journal of Clinical Pathologyen
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