Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen.
Authors
O'Connor, James P BNaish, Josephine H
Jackson, Alan
Waterton, John C
Watson, Yvonne
Cheung, Susan
Buckley, David L
McGrath, Deirdre M
Buonaccorsi, Giovanni A
Mills, Samantha J
Roberts, Caleb
Jayson, Gordon C
Parker, Geoff J M
Affiliation
Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK.Issue Date
2009-01
Metadata
Show full item recordAbstract
Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this study differences in the tissue longitudinal relaxation rate (R(1)) and effective transverse relaxation rate (R(*)(2)), induced by inhalation of pure oxygen and carbogen, were evaluated in 10 healthy subjects. Significant reductions in R(1) were demonstrated following both oxygen and carbogen inhalation in the spleen (both P < 0.001), liver (P = 0.002 air vs. oxygen; P = 0.001 air vs. carbogen), skeletal muscle (both P < 0.001), and renal cortex (P = 0.005 air vs. oxygen; P = 0.008 air vs. carbogen). No significant change in R(*)(2) occurred following pure oxygen in any organ. However, a significant increase in R(*)(2) was observed in the spleen (P < 0.001), liver (P = 0.001), skeletal muscle (P = 0.026), and renal cortex (P = 0.001) following carbogen inhalation, an opposite effect to that observed in many studies of tumor pathophysiology. Changes in R(1) and R(*)(2) were independent of the gas administration order in the spleen and skeletal muscle. These findings suggest that the R(1) and R(*)(2) responses to hyperoxic gases are independent biomarkers of oxygen physiology.Citation
Comparison of normal tissue R1 and R*2 modulation by oxygen and carbogen. 2009, 61 (1):75-83notMagn Reson MedJournal
Magnetic Resonance in Medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in MedicineDOI
10.1002/mrm.21815PubMed ID
19097212Type
ArticleLanguage
enISSN
1522-2594ae974a485f413a2113503eed53cd6c53
10.1002/mrm.21815