Serum Insulin-like Growth Factor-I and its Binding Protein 3 in their Relation to Intima Media Thickness: Results of the Study of Health in Pomerania (SHIP).
Authors
Spilcke-Liss, EFriedrich, N
Dörr, M
Schminke, U
Völzke, H
Brabant, Georg E
Nauck, M
Wallaschofski, H
Affiliation
Institute of Clinical Chemistry and Laboratory Medicine Department of Cardiology Department of Neurology Institute for Community Medicine University of Greifswald, Germany Department of Endocrinology, Christie Hospital, Manchester, UK.Issue Date
2011-02-09
Metadata
Show full item recordAbstract
Objective: Previous studies detected associations between lower insulin-like growth factor I (IGF-I) levels and increased risk of congestive heart failure or ischemic heart disease. The aim of the present study was to assess the association of IGF-I and its binding protein 3 (IGFBP-3) with the carotid intima-media thickness (IMT) as marker of asymptomatic cardiovascular disease. Design and population: From the population-based Study of Health in Pomerania (SHIP), a total of 2,286 participants aged 45 years or older with readable ultrasound of the carotid arteries were available for the present analyses. Methods and measurements: Serum IGF-I and IGFBP-3 levels were categorized into three groups (low, moderate, high) according to the sex-specific 10th and 90th percentile. Analyses of variance (ANOVA) and logistic regression analyses adjusted for age, waist circumference, diabetes, hypertension, and creatinine clearance were performed. Results: After adjusting for confounding factors, IGF-I and the IGF-I/IGFBP3 ratio were positively related to IMT in analyses of variance. Logistic regression analyses confirmed these findings and showed that high IGF-I levels, a high IGF-I/IGFBP3 ratio, and low IGFBP-3 levels were associated to higher odds of increased IMT. Conclusion: In conclusion, high IGF-I or high IGF-I/IGFBP3 ratio values and low IGFBP-3 levels are associated with increased IMT. Therefore systemic levels of the IGF axis or alterations in the balance of its components are associated with subclinical atherosclerotic disease.Citation
Serum Insulin-like Growth Factor-I and its Binding Protein 3 in their Relation to Intima Media Thickness: Results of the Study of Health in Pomerania (SHIP). 2011, 75(1):70-75 Clin EndocrinolJournal
Clinical EndocrinologyDOI
10.1111/j.1365-2265.2011.04010.xPubMed ID
21521279Type
ArticleLanguage
enISSN
1365-2265ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2265.2011.04010.x
Scopus Count
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