Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [¹⁸F]-IL1RA and PET imaging in rats.
Authors
Cawthorne, ChristopherPrenant, C
Smigova, A
Julyan, Peter J
Maroy, R
Herholz, K
Rothwell, N
Boutin, H
Affiliation
Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.Issue Date
2011-02
Metadata
Show full item recordAbstract
Positron emission tomography (PET) has the potential to improve our understanding of the preclinical pharmacokinetics and metabolism of therapeutic agents, and is easily translated to clinical studies in humans. However, studies involving proteins radiolabelled with clinically relevant PET isotopes are currently limited. Here we illustrate the potential of PET imaging in a preclinical study of the biodistribution and metabolism of ¹⁸F-labelled IL-1 receptor antagonist ([¹⁸F]IL-1RA) using a novel [¹⁸F]-radiolabelling technique.Citation
Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [¹⁸F]-IL1RA and PET imaging in rats. 2011, 162 (3):659-72 Br. J. Pharmacol.Journal
British Journal of PharmacologyDOI
10.1111/j.1476-5381.2010.01068.xPubMed ID
20942812Type
ArticleLanguage
enISSN
1476-5381ae974a485f413a2113503eed53cd6c53
10.1111/j.1476-5381.2010.01068.x