N-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109888
Title:
N-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS.
Authors:
Dias, P; Kumar, Patricia; Marsden, Henry B; Gattamaneni, Rao; Heighway, Jim; Kumar, Shant
Abstract:
DNA from 13 (6 alveolar and 7 embryonal) childhood rhabdomyosarcomas (RMS) was examined to determine the incidence and prognostic relevance of N- and c-myc genes. Southern analysis showed 5- to 20-fold amplification of N-myc gene in 4 of 6 alveolar but in none of 7 embryonal RMS (p less than 0.04; Fisher's exact test). The number of children who died with multiple- and single-copy N-myc gene was 4/4 and 5/9 respectively (p greater than 0.05; Chi-squared test). There was no statistically significant correlation between N-myc amplification and age, gender, site, stage or survival time. There was no amplification or gross rearrangement of c-myc in any of the 13 RMS.
Affiliation:
Christie Hospital and Holt Radium Institute, Withington, Manchester, UK.
Citation:
N-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS. 1990, 45 (4):593-6 Int. J. Cancer
Journal:
International Journal of Cancer
Issue Date:
15-Apr-1990
URI:
http://hdl.handle.net/10541/109888
DOI:
10.1002/ijc.2910450403
PubMed ID:
2323837
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDias, Pen
dc.contributor.authorKumar, Patriciaen
dc.contributor.authorMarsden, Henry Ben
dc.contributor.authorGattamaneni, Raoen
dc.contributor.authorHeighway, Jimen
dc.contributor.authorKumar, Shanten
dc.date.accessioned2010-08-18T15:22:17Z-
dc.date.available2010-08-18T15:22:17Z-
dc.date.issued1990-04-15-
dc.identifier.citationN-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS. 1990, 45 (4):593-6 Int. J. Canceren
dc.identifier.issn0020-7136-
dc.identifier.pmid2323837-
dc.identifier.doi10.1002/ijc.2910450403-
dc.identifier.urihttp://hdl.handle.net/10541/109888-
dc.description.abstractDNA from 13 (6 alveolar and 7 embryonal) childhood rhabdomyosarcomas (RMS) was examined to determine the incidence and prognostic relevance of N- and c-myc genes. Southern analysis showed 5- to 20-fold amplification of N-myc gene in 4 of 6 alveolar but in none of 7 embryonal RMS (p less than 0.04; Fisher's exact test). The number of children who died with multiple- and single-copy N-myc gene was 4/4 and 5/9 respectively (p greater than 0.05; Chi-squared test). There was no statistically significant correlation between N-myc amplification and age, gender, site, stage or survival time. There was no amplification or gross rearrangement of c-myc in any of the 13 RMS.en
dc.language.isoenen
dc.subjectCancer DNAen
dc.subject.meshBlotting, Southern-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshFemale-
dc.subject.meshGene Amplification-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshMale-
dc.subject.meshOncogenes-
dc.subject.meshPrognosis-
dc.subject.meshRhabdomyosarcoma-
dc.titleN-myc gene is amplified in alveolar rhabdomyosarcomas (RMS) but not in embryonal RMS.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital and Holt Radium Institute, Withington, Manchester, UK.en
dc.identifier.journalInternational Journal of Canceren

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