Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109883
Title:
Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia.
Authors:
Chang, James; Craft, A W; Reid, M M; Coutinho, Lucia H; Dexter, T Michael
Abstract:
Severe congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia.
Affiliation:
Department of Haematology, Christie Hospital, Manchester, United Kingdom.
Citation:
Lack of response of bone marrow, in vitro, to growth factors in congenital neutropenia. 1990, 35 (2):125-6 Am. J. Hematol.
Journal:
American Journal of Hematology
Issue Date:
Oct-1990
URI:
http://hdl.handle.net/10541/109883
DOI:
10.1002/ajh.2830350212
PubMed ID:
1698019
Type:
Article
Language:
en
ISSN:
0361-8609
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorChang, Jamesen
dc.contributor.authorCraft, A Wen
dc.contributor.authorReid, M Men
dc.contributor.authorCoutinho, Lucia Hen
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-08-18T15:09:54Z-
dc.date.available2010-08-18T15:09:54Z-
dc.date.issued1990-10-
dc.identifier.citationLack of response of bone marrow, in vitro, to growth factors in congenital neutropenia. 1990, 35 (2):125-6 Am. J. Hematol.en
dc.identifier.issn0361-8609-
dc.identifier.pmid1698019-
dc.identifier.doi10.1002/ajh.2830350212-
dc.identifier.urihttp://hdl.handle.net/10541/109883-
dc.description.abstractSevere congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia.en
dc.language.isoenen
dc.subject.meshAgranulocytosis-
dc.subject.meshBone Marrow-
dc.subject.meshCells, Cultured-
dc.subject.meshChild-
dc.subject.meshColony-Forming Units Assay-
dc.subject.meshColony-Stimulating Factors-
dc.subject.meshGranulocyte Colony-Stimulating Factor-
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor-
dc.subject.meshGrowth Substances-
dc.subject.meshHumans-
dc.subject.meshInterleukin-3-
dc.subject.meshMale-
dc.subject.meshNeutropenia-
dc.subject.meshRecombinant Proteins-
dc.titleLack of response of bone marrow, in vitro, to growth factors in congenital neutropenia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalAmerican Journal of Hematologyen

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