Long-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109881
Title:
Long-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time.
Authors:
Chang, James; Geary, C; Testa, Nydia G
Abstract:
Thirteen patients with acute myeloid leukaemia (AML) who had been in unmaintained complete remission for at least 5 years following successful chemotherapy, were studied by marrow culture techniques regularly for periods of up to 5 years. In 10 patients, short-term clonal assay revealed the incidence of granulocyte-macrophage progenitor cells (GM-CFC) to be at the lower limit of the normal range; but three showed wide fluctuations in GM-CFC numbers. Moreover the generation of GM-CFC in long-term bone marrow culture (LTBMC) was impaired in eight of nine evaluable patients. These results suggest that, despite normal blood counts, impairment of haemopoiesis persists in patients who are long-term survivors of AML, and this does not improve with the passage of time.
Affiliation:
Department of Haematology, Paterson Laboratory, Christie Hospital, Manchester.
Citation:
Long-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time. 1990, 75 (1):68-72 Br. J. Haematol.
Journal:
British Journal of Haematology
Issue Date:
May-1990
URI:
http://hdl.handle.net/10541/109881
DOI:
10.1111/j.1365-2141.1990.tb02617.x
PubMed ID:
2375926
Type:
Article
Language:
en
ISSN:
0007-1048
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorChang, Jamesen
dc.contributor.authorGeary, Cen
dc.contributor.authorTesta, Nydia Gen
dc.date.accessioned2010-08-18T15:04:54Z-
dc.date.available2010-08-18T15:04:54Z-
dc.date.issued1990-05-
dc.identifier.citationLong-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time. 1990, 75 (1):68-72 Br. J. Haematol.en
dc.identifier.issn0007-1048-
dc.identifier.pmid2375926-
dc.identifier.doi10.1111/j.1365-2141.1990.tb02617.x-
dc.identifier.urihttp://hdl.handle.net/10541/109881-
dc.description.abstractThirteen patients with acute myeloid leukaemia (AML) who had been in unmaintained complete remission for at least 5 years following successful chemotherapy, were studied by marrow culture techniques regularly for periods of up to 5 years. In 10 patients, short-term clonal assay revealed the incidence of granulocyte-macrophage progenitor cells (GM-CFC) to be at the lower limit of the normal range; but three showed wide fluctuations in GM-CFC numbers. Moreover the generation of GM-CFC in long-term bone marrow culture (LTBMC) was impaired in eight of nine evaluable patients. These results suggest that, despite normal blood counts, impairment of haemopoiesis persists in patients who are long-term survivors of AML, and this does not improve with the passage of time.en
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectAcute Myeloid Leukaemiaen
dc.subjectTumour Stem Cell Assayen
dc.subject.meshAdult-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshBone Marrow-
dc.subject.meshFemale-
dc.subject.meshGranulocytes-
dc.subject.meshHematopoiesis-
dc.subject.meshHumans-
dc.subject.meshLeukemia, Myeloid, Acute-
dc.subject.meshMacrophages-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshRemission Induction-
dc.subject.meshTime Factors-
dc.subject.meshTumor Stem Cell Assay-
dc.titleLong-term bone marrow damage after chemotherapy for acute myeloid leukaemia does not improve with time.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Paterson Laboratory, Christie Hospital, Manchester.en
dc.identifier.journalBritish Journal of Haematologyen

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