A comparison of the sensitivity to photodynamic treatment of endothelial and tumour cells in different proliferative states.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109854
Title:
A comparison of the sensitivity to photodynamic treatment of endothelial and tumour cells in different proliferative states.
Authors:
West, Catharine M L; West, David C; Kumar, Shant; Moore, James V
Abstract:
Bovine aorta endothelial and human colon adenocarcinoma (WiDr) cells were exposed to haematoporphyrin derivative plus light. Cell survival was determined using a [3H]thymidine incorporation and a clonogenic assay for both cell types. The endothelial cells were more sensitive to photodynamic treatment. This could be explained in terms of increased drug uptake into the endothelial cells despite there being no difference in cell volume between the cells. For both tumour and endothelial cells, exponentially growing cells were more sensitive to photodynamic treatment than plateau-phase cells. This was associated with a reduction in drug uptake into plateau-phase endothelial cells. However, there was no difference in uptake into exponentially growing and plateau-phase WiDr cells.
Affiliation:
CRC Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
A comparison of the sensitivity to photodynamic treatment of endothelial and tumour cells in different proliferative states. 1990, 58 (1):145-56 Int. J. Radiat. Biol.
Journal:
International Journal of Radiation Biology
Issue Date:
Jul-1990
URI:
http://hdl.handle.net/10541/109854
DOI:
10.1080/09553009014551501
PubMed ID:
1973432
Type:
Article
Language:
en
ISSN:
0955-3002
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWest, Catharine M Len
dc.contributor.authorWest, David Cen
dc.contributor.authorKumar, Shanten
dc.contributor.authorMoore, James Ven
dc.date.accessioned2010-08-18T13:25:24Z-
dc.date.available2010-08-18T13:25:24Z-
dc.date.issued1990-07-
dc.identifier.citationA comparison of the sensitivity to photodynamic treatment of endothelial and tumour cells in different proliferative states. 1990, 58 (1):145-56 Int. J. Radiat. Biol.en
dc.identifier.issn0955-3002-
dc.identifier.pmid1973432-
dc.identifier.doi10.1080/09553009014551501-
dc.identifier.urihttp://hdl.handle.net/10541/109854-
dc.description.abstractBovine aorta endothelial and human colon adenocarcinoma (WiDr) cells were exposed to haematoporphyrin derivative plus light. Cell survival was determined using a [3H]thymidine incorporation and a clonogenic assay for both cell types. The endothelial cells were more sensitive to photodynamic treatment. This could be explained in terms of increased drug uptake into the endothelial cells despite there being no difference in cell volume between the cells. For both tumour and endothelial cells, exponentially growing cells were more sensitive to photodynamic treatment than plateau-phase cells. This was associated with a reduction in drug uptake into plateau-phase endothelial cells. However, there was no difference in uptake into exponentially growing and plateau-phase WiDr cells.en
dc.language.isoenen
dc.subjectCultured Tumour Cellsen
dc.subjectHaematoporphyrin Photoradiationen
dc.subject.meshAnimals-
dc.subject.meshCattle-
dc.subject.meshCell Cycle-
dc.subject.meshCell Line-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshHematoporphyrin Photoradiation-
dc.subject.meshHumans-
dc.subject.meshPhotochemotherapy-
dc.subject.meshTumor Cells, Cultured-
dc.titleA comparison of the sensitivity to photodynamic treatment of endothelial and tumour cells in different proliferative states.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalInternational Journal of Radiation Biologyen
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