2.50
Hdl Handle:
http://hdl.handle.net/10541/109851
Title:
The architecture of bone marrow cell populations.
Authors:
Lord, Brian I
Abstract:
Marrow is a loosely bound tissue in which hemopoiesis has frequently been considered to be randomly distributed. The case is presented, however, for an organized and structured marrow in which close relationships exist between hemopoietic tissue and a regulatory microenvironment. Distributions of myeloid cells in the mouse femur are described, and a dynamic picture of their movement, with differentiation and maturation from the endosteal surface of the bone to their release via the central venous sinus, is painted. It is also shown that this structure is established within three weeks of birth. By contrast, mature lymphoid cells (but not their progenitors) are uniformly distributed. Regulatory stromal elements in the marrow are also structured and their localization is found to correspond closely to the properties of the progenitor populations. Such structure has potential practical importance, particularly in the field of medical, industrial or accidental radiation exposure where bone may introduce non-uniform dose distributions in the marrow.
Affiliation:
Cancer Research Campaign Department of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital & Holt Radium Institute, Manchester, England.
Citation:
The architecture of bone marrow cell populations. 1990, 8 (5):317-31 Int. J. Cell Cloning
Journal:
International Journal of Cell Cloning
Issue Date:
Sep-1990
URI:
http://hdl.handle.net/10541/109851
DOI:
10.1002/stem.5530080501
PubMed ID:
2230283
Type:
Article
Language:
en
ISSN:
0737-1454
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLord, Brian Ien
dc.date.accessioned2010-08-18T13:22:40Z-
dc.date.available2010-08-18T13:22:40Z-
dc.date.issued1990-09-
dc.identifier.citationThe architecture of bone marrow cell populations. 1990, 8 (5):317-31 Int. J. Cell Cloningen
dc.identifier.issn0737-1454-
dc.identifier.pmid2230283-
dc.identifier.doi10.1002/stem.5530080501-
dc.identifier.urihttp://hdl.handle.net/10541/109851-
dc.description.abstractMarrow is a loosely bound tissue in which hemopoiesis has frequently been considered to be randomly distributed. The case is presented, however, for an organized and structured marrow in which close relationships exist between hemopoietic tissue and a regulatory microenvironment. Distributions of myeloid cells in the mouse femur are described, and a dynamic picture of their movement, with differentiation and maturation from the endosteal surface of the bone to their release via the central venous sinus, is painted. It is also shown that this structure is established within three weeks of birth. By contrast, mature lymphoid cells (but not their progenitors) are uniformly distributed. Regulatory stromal elements in the marrow are also structured and their localization is found to correspond closely to the properties of the progenitor populations. Such structure has potential practical importance, particularly in the field of medical, industrial or accidental radiation exposure where bone may introduce non-uniform dose distributions in the marrow.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals-
dc.subject.meshBone Marrow Cells-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHumans-
dc.titleThe architecture of bone marrow cell populations.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Experimental Hematology, Paterson Institute for Cancer Research, Christie Hospital & Holt Radium Institute, Manchester, England.en
dc.identifier.journalInternational Journal of Cell Cloningen
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