Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14-q15.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109850
Title:
Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14-q15.
Authors:
Boyle, John M; Grzeschik, K H; Heath, P R; Morten, J E; Stern, Peter L
Abstract:
Human X rodent hybrids were stained by indirect immunofluorescence with 5T4, a murine monoclonal antibody that recognises a 72 kdalton glycoprotein expressed by human trophoblasts and a very restricted range of adult tissues; they were analysed by flow cytometry. Concordance analysis supported by segregation data allowed assignment of the gene controlling glycoprotein expression (M6P1) to chromosome 6. Similar analysis with translocation hybrids gave a regional assignment to 6q14-q15. M6P1 is distinct from NT5, coding for 5' nucleotidase, which maps to the same region.
Affiliation:
Department of Biochemical Genetics, Paterson Institute of Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
Citation:
Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14-q15. 1990, 84 (5):455-8 Hum. Genet.
Journal:
Human Genetics
Issue Date:
Apr-1990
URI:
http://hdl.handle.net/10541/109850
DOI:
10.1007/BF00195819
PubMed ID:
2323778
Type:
Article
Language:
en
ISSN:
0340-6717
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBoyle, John Men
dc.contributor.authorGrzeschik, K Hen
dc.contributor.authorHeath, P Ren
dc.contributor.authorMorten, J Een
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-08-18T13:19:19Z-
dc.date.available2010-08-18T13:19:19Z-
dc.date.issued1990-04-
dc.identifier.citationTrophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14-q15. 1990, 84 (5):455-8 Hum. Genet.en
dc.identifier.issn0340-6717-
dc.identifier.pmid2323778-
dc.identifier.doi10.1007/BF00195819-
dc.identifier.urihttp://hdl.handle.net/10541/109850-
dc.description.abstractHuman X rodent hybrids were stained by indirect immunofluorescence with 5T4, a murine monoclonal antibody that recognises a 72 kdalton glycoprotein expressed by human trophoblasts and a very restricted range of adult tissues; they were analysed by flow cytometry. Concordance analysis supported by segregation data allowed assignment of the gene controlling glycoprotein expression (M6P1) to chromosome 6. Similar analysis with translocation hybrids gave a regional assignment to 6q14-q15. M6P1 is distinct from NT5, coding for 5' nucleotidase, which maps to the same region.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshBiological Markers-
dc.subject.meshChromosome Banding-
dc.subject.meshChromosomes, Human, Pair 6-
dc.subject.meshCricetinae-
dc.subject.meshCricetulus-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshHumans-
dc.subject.meshHybrid Cells-
dc.subject.meshMembrane Glycoproteins-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Proteins-
dc.subject.meshTrophoblasts-
dc.titleTrophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14-q15.en
dc.typeArticleen
dc.contributor.departmentDepartment of Biochemical Genetics, Paterson Institute of Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalHuman Geneticsen

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