Analysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109844
Title:
Analysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units.
Authors:
Hendry, Jolyon H; Roberts, Stephen A
Abstract:
The analysis of 68 published sets of dose-incidence data for marrow failure in different species, using a double-log mortality function, indicates: (a) There is more heterogeneity, i.e. greater sums-of-squares per degree of freedom, within the data sets for mouse than for larger species (monkey, dog, sheep, goat, pig). (b) For mice the curves for acute doses are characterized by a D0 of about 100 cGy for tissue-rescuing units (or target cells), which are depleted at most to about 3 x 10(-4) at LD50. (c) Larger species are much less tolerant to target-cell depletion, the corresponding level being consistently in the range of 10(-2)-10(-3) at LD50. Also, the D0 is often lower (approximately 55 cGy), which is compatible in the dog with such a value for hemopoietic progenitor cells. (d) With larger species there is an unexpected reduction in heterogeneity when the dose rate is lower, which gives a D0 lower than expected and a higher extrapolate. It is concluded that the position and slope of the dose-incidence curves are compatible with interpretations based primarily on target-cell number and survival characteristics, modified by additional heterogeneity factors.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
Citation:
Analysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units. 1990, 122 (2):155-60 Radiat. Res.
Journal:
Radiation Research
Issue Date:
May-1990
URI:
http://hdl.handle.net/10541/109844
PubMed ID:
2139973
Type:
Article
Language:
en
ISSN:
0033-7587
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorRoberts, Stephen Aen
dc.date.accessioned2010-08-18T12:26:10Z-
dc.date.available2010-08-18T12:26:10Z-
dc.date.issued1990-05-
dc.identifier.citationAnalysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units. 1990, 122 (2):155-60 Radiat. Res.en
dc.identifier.issn0033-7587-
dc.identifier.pmid2139973-
dc.identifier.urihttp://hdl.handle.net/10541/109844-
dc.description.abstractThe analysis of 68 published sets of dose-incidence data for marrow failure in different species, using a double-log mortality function, indicates: (a) There is more heterogeneity, i.e. greater sums-of-squares per degree of freedom, within the data sets for mouse than for larger species (monkey, dog, sheep, goat, pig). (b) For mice the curves for acute doses are characterized by a D0 of about 100 cGy for tissue-rescuing units (or target cells), which are depleted at most to about 3 x 10(-4) at LD50. (c) Larger species are much less tolerant to target-cell depletion, the corresponding level being consistently in the range of 10(-2)-10(-3) at LD50. Also, the D0 is often lower (approximately 55 cGy), which is compatible in the dog with such a value for hemopoietic progenitor cells. (d) With larger species there is an unexpected reduction in heterogeneity when the dose rate is lower, which gives a D0 lower than expected and a higher extrapolate. It is concluded that the position and slope of the dose-incidence curves are compatible with interpretations based primarily on target-cell number and survival characteristics, modified by additional heterogeneity factors.en
dc.language.isoenen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals-
dc.subject.meshBone Marrow-
dc.subject.meshDogs-
dc.subject.meshDose-Response Relationship, Radiation-
dc.subject.meshGoats-
dc.subject.meshHaplorhini-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshMeta-Analysis as Topic-
dc.subject.meshRadiation Tolerance-
dc.subject.meshRats-
dc.subject.meshSheep-
dc.subject.meshSpecies Specificity-
dc.subject.meshSwine-
dc.titleAnalysis of dose-incidence relationships for marrow failure in different species, in terms of radiosensitivity of tissue-rescuing units.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalRadiation Researchen

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