Ultrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: the "neuro-reticular complex".

2.50
Hdl Handle:
http://hdl.handle.net/10541/109818
Title:
Ultrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: the "neuro-reticular complex".
Authors:
Yamazaki, K; Allen, Terence D
Abstract:
In order to extend our understanding of the role of nerve fibers in the structure and function of bone marrow stroma, we have examined nerve terminals, arterioles, and capillaries in femoral bone marrow tissues of 50 C57BL strain mice, using electron microscopy and morphometric methods. Within the adventitia of arterioles, a particular type of cell, termed periarterial adventitial (PAA) cell, is characterized by a thin veil-like cytoplasm which concentrically surrounds both nerves and arterioles. Nerve fibers containing both unmyelinated and myelinated axons are distributed mainly between the layers of PAA cells, but are found rarely on the sinus walls or within the hematopoietic parenchyma. Quantitatively, the efferent nerve terminals with many synaptic vesicles are distributed mainly beside arterial smooth muscle cells (Type I: 58.8%) or between the layers of PAA cells (Type III: 33.2%), and rarely in hematopoietic parenchyma (Type II: 5.3%) or on sinus walls (Type IV: 2.7%). In the case of Type II-IV nerve terminals, efferent (autonomic) nerves and bone marrow stromal cells which are connected by gap junctions (sinus adventitial reticular cells, intersinusoidal reticular cells, and PAA cells) appear to constitute a potential functional unit for signal conduction. We would like to propose a new term for this anatomical unit in marrow, the "neuro-reticular complex."
Affiliation:
Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
Citation:
Ultrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: the "neuro-reticular complex". 1990, 187 (3):261-76 Am. J. Anat.
Journal:
American Journal of Anatomy
Issue Date:
Mar-1990
URI:
http://hdl.handle.net/10541/109818
DOI:
10.1002/aja.1001870306
PubMed ID:
2321559
Type:
Article
Language:
en
ISSN:
0002-9106
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorYamazaki, Ken
dc.contributor.authorAllen, Terence Den
dc.date.accessioned2010-08-18T08:42:26Z-
dc.date.available2010-08-18T08:42:26Z-
dc.date.issued1990-03-
dc.identifier.citationUltrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: the "neuro-reticular complex". 1990, 187 (3):261-76 Am. J. Anat.en
dc.identifier.issn0002-9106-
dc.identifier.pmid2321559-
dc.identifier.doi10.1002/aja.1001870306-
dc.identifier.urihttp://hdl.handle.net/10541/109818-
dc.description.abstractIn order to extend our understanding of the role of nerve fibers in the structure and function of bone marrow stroma, we have examined nerve terminals, arterioles, and capillaries in femoral bone marrow tissues of 50 C57BL strain mice, using electron microscopy and morphometric methods. Within the adventitia of arterioles, a particular type of cell, termed periarterial adventitial (PAA) cell, is characterized by a thin veil-like cytoplasm which concentrically surrounds both nerves and arterioles. Nerve fibers containing both unmyelinated and myelinated axons are distributed mainly between the layers of PAA cells, but are found rarely on the sinus walls or within the hematopoietic parenchyma. Quantitatively, the efferent nerve terminals with many synaptic vesicles are distributed mainly beside arterial smooth muscle cells (Type I: 58.8%) or between the layers of PAA cells (Type III: 33.2%), and rarely in hematopoietic parenchyma (Type II: 5.3%) or on sinus walls (Type IV: 2.7%). In the case of Type II-IV nerve terminals, efferent (autonomic) nerves and bone marrow stromal cells which are connected by gap junctions (sinus adventitial reticular cells, intersinusoidal reticular cells, and PAA cells) appear to constitute a potential functional unit for signal conduction. We would like to propose a new term for this anatomical unit in marrow, the "neuro-reticular complex."en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshArterioles-
dc.subject.meshBone Marrow-
dc.subject.meshBone Marrow Cells-
dc.subject.meshCapillaries-
dc.subject.meshMice-
dc.subject.meshMice, Inbred C57BL-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMicroscopy, Electron, Scanning-
dc.subject.meshNerve Endings-
dc.subject.meshPeripheral Nerves-
dc.titleUltrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: the "neuro-reticular complex".en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, School of Medicine, Keio University, Tokyo, Japan.en
dc.identifier.journalAmerican Journal of Anatomyen
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