Tenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109811
Title:
Tenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma.
Authors:
Ferguson, Janice E; Schor, Ana M; Howell, Anthony ( 0000-0002-6233-719X ) ; Ferguson, M W
Abstract:
Tenascin is a novel extracellular matrix glycoprotein which appears to have a major role in tissue development. Previous studies have stated that tenascin is absent from the normal human, rat and mouse breast, its distribution being restricted to embryonic and malignant mammary tissues. No previous studies have investigated tenascin distribution as a function of the normal menstrual cycle. Therefore this study addresses the cyclical appearance of tenascin in the normal breast and associated changes in distribution in preinvasive cancer (carcinoma-in-situ) and invasive infiltrating ductal carcinoma. Tenascin is present in the normal human adult mammary gland, principally in the basement membrane, sub-basement-membrane zone and delimiting layer of fibroblasts around the ductules. Both the distribution and quantity of tenascin change during the menstrual cycle. In carcinoma-in-situ (preinvasive cancer) tenascin is present in the attenuated basement membrane/sub-basement-membrane zone around the expanded ductules and in small amounts in the stroma. In infiltrating ductal carcinoma, tenascin is absent from the remnants of the basement membrane and sub-basement-membrane zone but greatly increased in the adjacent intralobular and interlobular stroma. Therefore, if tenascin is used as a basement membrane/sub-basement-membrane marker for distinguishing carcinoma-in-situ from invasive ductal carcinoma, the time of the menstrual cycle is of importance in interpreting the biopsy appearance. This study suggests that the optimal time for biopsy is between weeks 3 and 4 of the cycle, to avoid confusion between the normal low levels of tenascin (due to hormonal status) and those due to microinvasive disease.(ABSTRACT TRUNCATED AT 250 WORDS)
Affiliation:
CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Withington, Manchester, England.
Citation:
Tenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma. 1990, 42 (3):199-207 Differentiation
Journal:
Differentiation
Issue Date:
Feb-1990
URI:
http://hdl.handle.net/10541/109811
DOI:
10.1111/j.1432-0436.1990.tb00762.x
PubMed ID:
1692795
Type:
Article
Language:
en
ISSN:
0301-4681
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFerguson, Janice Een
dc.contributor.authorSchor, Ana Men
dc.contributor.authorHowell, Anthonyen
dc.contributor.authorFerguson, M Wen
dc.date.accessioned2010-08-18T09:29:15Z-
dc.date.available2010-08-18T09:29:15Z-
dc.date.issued1990-02-
dc.identifier.citationTenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma. 1990, 42 (3):199-207 Differentiationen
dc.identifier.issn0301-4681-
dc.identifier.pmid1692795-
dc.identifier.doi10.1111/j.1432-0436.1990.tb00762.x-
dc.identifier.urihttp://hdl.handle.net/10541/109811-
dc.description.abstractTenascin is a novel extracellular matrix glycoprotein which appears to have a major role in tissue development. Previous studies have stated that tenascin is absent from the normal human, rat and mouse breast, its distribution being restricted to embryonic and malignant mammary tissues. No previous studies have investigated tenascin distribution as a function of the normal menstrual cycle. Therefore this study addresses the cyclical appearance of tenascin in the normal breast and associated changes in distribution in preinvasive cancer (carcinoma-in-situ) and invasive infiltrating ductal carcinoma. Tenascin is present in the normal human adult mammary gland, principally in the basement membrane, sub-basement-membrane zone and delimiting layer of fibroblasts around the ductules. Both the distribution and quantity of tenascin change during the menstrual cycle. In carcinoma-in-situ (preinvasive cancer) tenascin is present in the attenuated basement membrane/sub-basement-membrane zone around the expanded ductules and in small amounts in the stroma. In infiltrating ductal carcinoma, tenascin is absent from the remnants of the basement membrane and sub-basement-membrane zone but greatly increased in the adjacent intralobular and interlobular stroma. Therefore, if tenascin is used as a basement membrane/sub-basement-membrane marker for distinguishing carcinoma-in-situ from invasive ductal carcinoma, the time of the menstrual cycle is of importance in interpreting the biopsy appearance. This study suggests that the optimal time for biopsy is between weeks 3 and 4 of the cycle, to avoid confusion between the normal low levels of tenascin (due to hormonal status) and those due to microinvasive disease.(ABSTRACT TRUNCATED AT 250 WORDS)en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Invasivenessen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshBreast-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma, Intraductal, Noninfiltrating-
dc.subject.meshCell Adhesion Molecules, Neuronal-
dc.subject.meshFemale-
dc.subject.meshFluorescent Antibody Technique-
dc.subject.meshHumans-
dc.subject.meshMenstrual Cycle-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshTenascin-
dc.titleTenascin distribution in the normal human breast is altered during the menstrual cycle and in carcinoma.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Withington, Manchester, England.en
dc.identifier.journalDifferentiationen

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