Additive interaction between tamoxifen and rifampicin in human biliary tract carcinoma cells.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109809
Title:
Additive interaction between tamoxifen and rifampicin in human biliary tract carcinoma cells.
Authors:
West, Catharine M L; Reeves, S J; Brough, W
Abstract:
A novel two-drug combination of tamoxifen and rifampicin has been investigated for the treatment of biliary tract-associated malignancies. Their effects, alone and in combination, on human tumour cells were studied using two pancreatic carcinoma cell lines. MIA PaCa-2 and AsPC-1, and a gall bladder carcinoma cell line, G-415. Inhibition of growth was used as an endpoint. The cells differed in sensitivity to equimolar doses of the two drugs given as single agents. Combined doses of rifampicin and tamoxifen resulted in growth inhibition to an extent that was suggestive of additive or synergistic drug effects. More detailed analysis was carried out, involving the production of an 'envelope of additivity' for each cell line. An additive effect of drug combination was shown to occur in all three cell lines, thus providing a basis for use of this novel two-drug combination in the treatment of biliary tract-associated malignancies.
Affiliation:
Department of Radiobiology, Paterson Institute for Cancer Research, Manchester, U.K.
Citation:
Additive interaction between tamoxifen and rifampicin in human biliary tract carcinoma cells. 1990, 55 (2):159-63 Cancer Lett.
Journal:
Cancer Letters
Issue Date:
3-Dec-1990
URI:
http://hdl.handle.net/10541/109809
DOI:
10.1016/0304-3835(90)90027-U
PubMed ID:
2265416
Type:
Article
Language:
en
ISSN:
0304-3835
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWest, Catharine M Len
dc.contributor.authorReeves, S Jen
dc.contributor.authorBrough, Wen
dc.date.accessioned2010-08-18T09:22:55Z-
dc.date.available2010-08-18T09:22:55Z-
dc.date.issued1990-12-03-
dc.identifier.citationAdditive interaction between tamoxifen and rifampicin in human biliary tract carcinoma cells. 1990, 55 (2):159-63 Cancer Lett.en
dc.identifier.issn0304-3835-
dc.identifier.pmid2265416-
dc.identifier.doi10.1016/0304-3835(90)90027-U-
dc.identifier.urihttp://hdl.handle.net/10541/109809-
dc.description.abstractA novel two-drug combination of tamoxifen and rifampicin has been investigated for the treatment of biliary tract-associated malignancies. Their effects, alone and in combination, on human tumour cells were studied using two pancreatic carcinoma cell lines. MIA PaCa-2 and AsPC-1, and a gall bladder carcinoma cell line, G-415. Inhibition of growth was used as an endpoint. The cells differed in sensitivity to equimolar doses of the two drugs given as single agents. Combined doses of rifampicin and tamoxifen resulted in growth inhibition to an extent that was suggestive of additive or synergistic drug effects. More detailed analysis was carried out, involving the production of an 'envelope of additivity' for each cell line. An additive effect of drug combination was shown to occur in all three cell lines, thus providing a basis for use of this novel two-drug combination in the treatment of biliary tract-associated malignancies.en
dc.language.isoenen
dc.subjectBiliary Tract Canceren
dc.subjectGallbladder Canceren
dc.subjectPancreatic Canceren
dc.subjectCultured Tumour Cellsen
dc.subject.meshBiliary Tract Neoplasms-
dc.subject.meshCell Division-
dc.subject.meshDrug Interactions-
dc.subject.meshDrug Synergism-
dc.subject.meshDrug Therapy, Combination-
dc.subject.meshGallbladder Neoplasms-
dc.subject.meshHumans-
dc.subject.meshPancreatic Neoplasms-
dc.subject.meshRifampin-
dc.subject.meshTamoxifen-
dc.subject.meshTumor Cells, Cultured-
dc.titleAdditive interaction between tamoxifen and rifampicin in human biliary tract carcinoma cells.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiobiology, Paterson Institute for Cancer Research, Manchester, U.K.en
dc.identifier.journalCancer Lettersen

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