The biochemistry and biology of the myeloid haemopoietic cell growth factors.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109795
Title:
The biochemistry and biology of the myeloid haemopoietic cell growth factors.
Authors:
Heyworth, Clare M; Vallance, S J; Whetton, Anthony D; Dexter, T Michael
Abstract:
In the adult, blood cell production or haemopoiesis takes place mainly in the bone marrow. The blood cell types produced are a reflection of the needs of the organism at any moment, for example bacterial infection leads to a large increase in neutrophil production. The rate and scale of blood cell production in vivo are regulated, at least in part, by the synthesis and release of specific cytokines both within the bone marrow and also from other tissues. Here we detail the range of cytokines which act directly on haemopoietic stem cells and myeloid progenitor cells. Also cellular systems which will permit the elucidation of the specific interactions between these various cytokines which regulate stem cell self-renewal, differentiation and proliferation are described.
Affiliation:
Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
Citation:
The biochemistry and biology of the myeloid haemopoietic cell growth factors. 1990, 13:57-74 J. Cell Sci. Suppl.
Journal:
Journal of Cell Science. Supplement
Issue Date:
1990
URI:
http://hdl.handle.net/10541/109795
PubMed ID:
2084118
Type:
Article
Language:
en
ISSN:
0269-3518
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHeyworth, Clare Men
dc.contributor.authorVallance, S Jen
dc.contributor.authorWhetton, Anthony Den
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-08-18T08:25:36Z-
dc.date.available2010-08-18T08:25:36Z-
dc.date.issued1990-
dc.identifier.citationThe biochemistry and biology of the myeloid haemopoietic cell growth factors. 1990, 13:57-74 J. Cell Sci. Suppl.en
dc.identifier.issn0269-3518-
dc.identifier.pmid2084118-
dc.identifier.urihttp://hdl.handle.net/10541/109795-
dc.description.abstractIn the adult, blood cell production or haemopoiesis takes place mainly in the bone marrow. The blood cell types produced are a reflection of the needs of the organism at any moment, for example bacterial infection leads to a large increase in neutrophil production. The rate and scale of blood cell production in vivo are regulated, at least in part, by the synthesis and release of specific cytokines both within the bone marrow and also from other tissues. Here we detail the range of cytokines which act directly on haemopoietic stem cells and myeloid progenitor cells. Also cellular systems which will permit the elucidation of the specific interactions between these various cytokines which regulate stem cell self-renewal, differentiation and proliferation are described.en
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals-
dc.subject.meshBone Marrow-
dc.subject.meshGrowth Substances-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHumans-
dc.subject.meshInterleukins-
dc.titleThe biochemistry and biology of the myeloid haemopoietic cell growth factors.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalJournal of Cell Science. Supplementen

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