Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109756
Title:
Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor.
Authors:
Molineux, Graham; Pojda, Z; Hampson, Ian N; Lord, Brian I; Dexter, T Michael
Abstract:
The major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow transplantation in humans, primates and rodents. In addition, it has been reported that migration of committed progenitor cells to the blood occurs during G-CSF therapy. In this article, by using sex mismatched transplants and a molecular probe for Y-chromosome specific DNA sequences, we show that among the peripheral blood cells during G-CSF therapy are substantial numbers of primitive stem cells capable of (1) reconstituting the hematopoietic system in the long term, and (2) making a contribution to the lymphoid populations of the thymus, in radiation ablated recipients. These data suggest that blood from patients treated with G-CSF may provide a convenient source of the most primitive stem cells for autologous or allogeneic bone marrow transplantation.
Affiliation:
Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.
Citation:
Transplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. 1990, 76 (10):2153-8 Blood
Journal:
Blood
Issue Date:
15-Nov-1990
URI:
http://hdl.handle.net/10541/109756
PubMed ID:
1700732
Type:
Article
Language:
en
ISSN:
0006-4971
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMolineux, Grahamen
dc.contributor.authorPojda, Zen
dc.contributor.authorHampson, Ian Nen
dc.contributor.authorLord, Brian Ien
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-08-17T11:29:41Z-
dc.date.available2010-08-17T11:29:41Z-
dc.date.issued1990-11-15-
dc.identifier.citationTransplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor. 1990, 76 (10):2153-8 Blooden
dc.identifier.issn0006-4971-
dc.identifier.pmid1700732-
dc.identifier.urihttp://hdl.handle.net/10541/109756-
dc.description.abstractThe major effect of granulocyte colony-stimulating factor (G-CSF) is to induce neutrophilia in previously untreated animals or after chemotherapy or marrow transplantation in humans, primates and rodents. In addition, it has been reported that migration of committed progenitor cells to the blood occurs during G-CSF therapy. In this article, by using sex mismatched transplants and a molecular probe for Y-chromosome specific DNA sequences, we show that among the peripheral blood cells during G-CSF therapy are substantial numbers of primitive stem cells capable of (1) reconstituting the hematopoietic system in the long term, and (2) making a contribution to the lymphoid populations of the thymus, in radiation ablated recipients. These data suggest that blood from patients treated with G-CSF may provide a convenient source of the most primitive stem cells for autologous or allogeneic bone marrow transplantation.en
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Stem Cellsen
dc.subject.meshAnimals-
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshFemale-
dc.subject.meshGraft Survival-
dc.subject.meshGranulocyte Colony-Stimulating Factor-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshNeutrophils-
dc.titleTransplantation potential of peripheral blood stem cells induced by granulocyte colony-stimulating factor.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, UK.en
dc.identifier.journalBlooden

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