2.50
Hdl Handle:
http://hdl.handle.net/10541/109742
Title:
Cell lineages in haemopoiesis: comments on their regulation.
Authors:
Testa, Nydia G; Dexter, T Michael
Abstract:
The regulation of cell production and the determination of cell lineage in haemopoiesis are the result of multiple processes involving cell-cell interactions and the action of specific haemopoietic growth factors as well as other cytokines. Additive and synergistic interactions between these factors, and also with those involved in the regulation of lymphopoiesis have been described, which involve modulation of the growth and differentiation of haematopoietic precursors. However, the mechanisms which determine the self-renewal and the differentiation of the pluripotent lymphohaemopoietic stem cell remain largely undefined.
Affiliation:
Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Cell lineages in haemopoiesis: comments on their regulation. 1990, 2 (3):167-72 Semin. Immunol.
Journal:
Seminars in Immunology
Issue Date:
May-1990
URI:
http://hdl.handle.net/10541/109742
PubMed ID:
1717053
Type:
Article
Language:
en
ISSN:
1044-5323
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorTesta, Nydia Gen
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-08-17T11:25:09Z-
dc.date.available2010-08-17T11:25:09Z-
dc.date.issued1990-05-
dc.identifier.citationCell lineages in haemopoiesis: comments on their regulation. 1990, 2 (3):167-72 Semin. Immunol.en
dc.identifier.issn1044-5323-
dc.identifier.pmid1717053-
dc.identifier.urihttp://hdl.handle.net/10541/109742-
dc.description.abstractThe regulation of cell production and the determination of cell lineage in haemopoiesis are the result of multiple processes involving cell-cell interactions and the action of specific haemopoietic growth factors as well as other cytokines. Additive and synergistic interactions between these factors, and also with those involved in the regulation of lymphopoiesis have been described, which involve modulation of the growth and differentiation of haematopoietic precursors. However, the mechanisms which determine the self-renewal and the differentiation of the pluripotent lymphohaemopoietic stem cell remain largely undefined.en
dc.language.isoenen
dc.subjectHaematopoiesisen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subject.meshAnimals-
dc.subject.meshCell Communication-
dc.subject.meshCell Differentiation-
dc.subject.meshErythropoietin-
dc.subject.meshGranulocyte Colony-Stimulating Factor-
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor-
dc.subject.meshHematopoiesis-
dc.subject.meshHematopoietic Cell Growth Factors-
dc.subject.meshHumans-
dc.subject.meshInterleukin-3-
dc.subject.meshMacrophage Colony-Stimulating Factor-
dc.subject.meshMice-
dc.subject.meshStem Cells-
dc.titleCell lineages in haemopoiesis: comments on their regulation.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalSeminars in Immunologyen

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