2.50
Hdl Handle:
http://hdl.handle.net/10541/109698
Title:
Autoimmune cytopenias in Castleman's disease.
Authors:
Carrington, P A; Anderson, Heather; Harris, Martin; Walsh, S E; Houghton, J B; Morgenstern, Godfrey R
Abstract:
The authors report a case of Castleman's disease in which the major clinical problems have been caused by severe thrombocytopenia and neutropenia. The cytopenias were caused by autoimmune destruction of mature cells as demonstrated by bone marrow findings and cell-specific antibody assays. There also was evidence of red cell autoantibody production but no overt hemolysis. The thrombocytopenia currently is controlled by intermittent vincristine, having proved refractory to steroids, splenectomy, and danazol and only partially responsive to high dose intravenous immunoglobulin. The neutropenia showed temporary improvement with immunoglobulin but has been resistant to all other therapy. This case provides further evidence for disordered immune regulation in Castleman's disease.
Affiliation:
Department of Hematology, Hope Hospital, Salford, United Kingdom.
Citation:
Autoimmune cytopenias in Castleman's disease. 1990, 94 (1):101-4 Am. J. Clin. Pathol.
Journal:
American Journal of Clinical Pathology
Issue Date:
Jul-1990
URI:
http://hdl.handle.net/10541/109698
PubMed ID:
2193504
Type:
Article
Language:
en
ISSN:
0002-9173
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCarrington, P Aen
dc.contributor.authorAnderson, Heatheren
dc.contributor.authorHarris, Martinen
dc.contributor.authorWalsh, S Een
dc.contributor.authorHoughton, J Ben
dc.contributor.authorMorgenstern, Godfrey Ren
dc.date.accessioned2010-08-17T08:58:02Z-
dc.date.available2010-08-17T08:58:02Z-
dc.date.issued1990-07-
dc.identifier.citationAutoimmune cytopenias in Castleman's disease. 1990, 94 (1):101-4 Am. J. Clin. Pathol.en
dc.identifier.issn0002-9173-
dc.identifier.pmid2193504-
dc.identifier.urihttp://hdl.handle.net/10541/109698-
dc.description.abstractThe authors report a case of Castleman's disease in which the major clinical problems have been caused by severe thrombocytopenia and neutropenia. The cytopenias were caused by autoimmune destruction of mature cells as demonstrated by bone marrow findings and cell-specific antibody assays. There also was evidence of red cell autoantibody production but no overt hemolysis. The thrombocytopenia currently is controlled by intermittent vincristine, having proved refractory to steroids, splenectomy, and danazol and only partially responsive to high dose intravenous immunoglobulin. The neutropenia showed temporary improvement with immunoglobulin but has been resistant to all other therapy. This case provides further evidence for disordered immune regulation in Castleman's disease.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAgranulocytosis-
dc.subject.meshAutoimmune Diseases-
dc.subject.meshFluorescent Antibody Technique-
dc.subject.meshGiant Lymph Node Hyperplasia-
dc.subject.meshGranulocytes-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshMale-
dc.subject.meshNeutropenia-
dc.subject.meshThrombocytopenia-
dc.titleAutoimmune cytopenias in Castleman's disease.en
dc.typeArticleen
dc.contributor.departmentDepartment of Hematology, Hope Hospital, Salford, United Kingdom.en
dc.identifier.journalAmerican Journal of Clinical Pathologyen

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