The inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109693
Title:
The inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours.
Authors:
Birch, Jillian M; Hartley, Ann L; Teare, M Dawn; Blair, Val; McKinney, Patricia A; Mann, J R; Stiller, C A; Draper, G J; Johnston, H E; Cartwright, R A
Abstract:
Tumours of the central nervous system comprise 23% of all childhood cancers and form the most common group of solid malignancies. Little is know about their aetiology. The present report concerns the results of a case-control study of 78 incident cases of central nervous system tumours in children. No case-control differences were detected for the following: pre-natal diagnostic X-rays, general anaesthetics during pregnancy, pregnancy infections, pregnancy drugs (including sedatives, tranquillizers and anti-convulsants), alcohol consumption in pregnancy, child's birthweight, breast-feeding, childhood illnesses, previous medication in the child. A significant excess of case mothers had suffered from diseases of the nervous system (RR 2.6). There was a deficit of children who had been immunised among the case children which approached significance, and an excess of congenital abnormalities among cases which also approached significance. There was a small excess of neoplastic disease among case parents. The results of this study suggest that in our patients genetic rather than environmental factors are more important, but the small numbers included in the present study meant that no definite conclusions could be reached.
Affiliation:
CRC Paediatric and Familial Cancer Research Group, Christie Hospital & Holt Radium Institute, Manchester, United Kingdom.
Citation:
The inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours. 1990, 4 (1):17-25 Br J Neurosurg
Journal:
British Journal of Neurosurgery
Issue Date:
1990
URI:
http://hdl.handle.net/10541/109693
DOI:
10.1002/bjs.1800770502
PubMed ID:
2334522
Type:
Article
Language:
en
ISSN:
0268-8697
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorHartley, Ann Len
dc.contributor.authorTeare, M Dawnen
dc.contributor.authorBlair, Valen
dc.contributor.authorMcKinney, Patricia Aen
dc.contributor.authorMann, J Ren
dc.contributor.authorStiller, C Aen
dc.contributor.authorDraper, G Jen
dc.contributor.authorJohnston, H Een
dc.contributor.authorCartwright, R Aen
dc.date.accessioned2010-08-17T08:23:39Z-
dc.date.available2010-08-17T08:23:39Z-
dc.date.issued1990-
dc.identifier.citationThe inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours. 1990, 4 (1):17-25 Br J Neurosurgen
dc.identifier.issn0268-8697-
dc.identifier.pmid2334522-
dc.identifier.doi10.1002/bjs.1800770502-
dc.identifier.urihttp://hdl.handle.net/10541/109693-
dc.description.abstractTumours of the central nervous system comprise 23% of all childhood cancers and form the most common group of solid malignancies. Little is know about their aetiology. The present report concerns the results of a case-control study of 78 incident cases of central nervous system tumours in children. No case-control differences were detected for the following: pre-natal diagnostic X-rays, general anaesthetics during pregnancy, pregnancy infections, pregnancy drugs (including sedatives, tranquillizers and anti-convulsants), alcohol consumption in pregnancy, child's birthweight, breast-feeding, childhood illnesses, previous medication in the child. A significant excess of case mothers had suffered from diseases of the nervous system (RR 2.6). There was a deficit of children who had been immunised among the case children which approached significance, and an excess of congenital abnormalities among cases which also approached significance. There was a small excess of neoplastic disease among case parents. The results of this study suggest that in our patients genetic rather than environmental factors are more important, but the small numbers included in the present study meant that no definite conclusions could be reached.en
dc.language.isoenen
dc.subjectNervous System Canceren
dc.subject.meshAbnormalities, Multiple-
dc.subject.meshCase-Control Studies-
dc.subject.meshCentral Nervous System Diseases-
dc.subject.meshChild-
dc.subject.meshFamily Health-
dc.subject.meshFemale-
dc.subject.meshGreat Britain-
dc.subject.meshHumans-
dc.subject.meshLabor, Obstetric-
dc.subject.meshMale-
dc.subject.meshNervous System Neoplasms-
dc.subject.meshOccupations-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Complications-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.subject.meshSocial Class-
dc.titleThe inter-regional epidemiological study of childhood cancer (IRESCC): case-control study of children with central nervous system tumours.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital & Holt Radium Institute, Manchester, United Kingdom.en
dc.identifier.journalBritish Journal of Neurosurgeryen

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