Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109658
Title:
Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy.
Authors:
Murphy, D; McGown, Alan T; Hall, A; Cattan, A; Crowther, Derek; Fox, Brian W
Abstract:
A study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response rates of these two groups to chemotherapy differ markedly, with patients who have relapsed following initial chemotherapy showing a reduction in response rates to subsequent chemotherapy. Analysis of these data show no statistically significant differences between the glutathione S-transferase activity or isoenzyme distribution in these two groups of patients. Significant differences were observed in the glutathione-S-transferase activities (GST) between tumours and normal ovaries. GST activities in pre-chemotherapy tumours (n = 33, P = 0.01) and post-chemotherapy tumours (n = 20, P = 0.001) where significantly higher than the GST activity in normal ovaries (n = 15). One feature was the expression of the basic isoenzyme which is expressed more in normal ovaries than in tumours. No differences in these parameters were observed in normal peritoneal tissue taken from patients before or after chemotherapy. These data do not support the hypothesis that changes in glutathione S-transferase enzyme activity or isoenzyme expression are major determinants of response to chemotherapy in ovarian tumours.
Affiliation:
CRC Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, UK.
Citation:
Glutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy. 1992, 66 (5):937-42 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Nov-1992
URI:
http://hdl.handle.net/10541/109658
PubMed ID:
1419640
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMurphy, Den
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorHall, Aen
dc.contributor.authorCattan, Aen
dc.contributor.authorCrowther, Dereken
dc.contributor.authorFox, Brian Wen
dc.date.accessioned2010-08-16T14:39:47Z-
dc.date.available2010-08-16T14:39:47Z-
dc.date.issued1992-11-
dc.identifier.citationGlutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy. 1992, 66 (5):937-42 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid1419640-
dc.identifier.urihttp://hdl.handle.net/10541/109658-
dc.description.abstractA study involving the measurement of glutathione S-transferase activities and isoenzyme distributions in human ovarian tumours has been carried out. These tumours have been obtained either at initial debulking surgery, prior to cytotoxic chemotherapy, or at second look laparotomy following chemotherapy. The response rates of these two groups to chemotherapy differ markedly, with patients who have relapsed following initial chemotherapy showing a reduction in response rates to subsequent chemotherapy. Analysis of these data show no statistically significant differences between the glutathione S-transferase activity or isoenzyme distribution in these two groups of patients. Significant differences were observed in the glutathione-S-transferase activities (GST) between tumours and normal ovaries. GST activities in pre-chemotherapy tumours (n = 33, P = 0.01) and post-chemotherapy tumours (n = 20, P = 0.001) where significantly higher than the GST activity in normal ovaries (n = 15). One feature was the expression of the basic isoenzyme which is expressed more in normal ovaries than in tumours. No differences in these parameters were observed in normal peritoneal tissue taken from patients before or after chemotherapy. These data do not support the hypothesis that changes in glutathione S-transferase enzyme activity or isoenzyme expression are major determinants of response to chemotherapy in ovarian tumours.en
dc.language.isoenen
dc.subjectAnticancerous Agentsen
dc.subjectAnticancerous Combined Chemotherapy Protocolsen
dc.subjectOvarian Canceren
dc.subject.meshAdult-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshBiopsy-
dc.subject.meshFemale-
dc.subject.meshGlutathione Transferase-
dc.subject.meshHumans-
dc.subject.meshIsoenzymes-
dc.subject.meshMiddle Aged-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshOvary-
dc.subject.meshPeritoneum-
dc.subject.meshTime Factors-
dc.titleGlutathione S-transferase activity and isoenzyme distribution in ovarian tumour biopsies taken before or after cytotoxic chemotherapy.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, UK.en
dc.identifier.journalBritish Journal of Canceren

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