Carcinoma of the cervix: an analysis of prognostic factors, treatment and patterns of failure following Wertheims hysterectomy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109652
Title:
Carcinoma of the cervix: an analysis of prognostic factors, treatment and patterns of failure following Wertheims hysterectomy.
Authors:
Logue, John P; Hale, R J; Wilcox, F L; Hunter, Robin D; Buckley, C H; Tindall, V R
Abstract:
A clinicopathologic analysis of 70 patients treated by radiotherapy and/or chemotherapy following primary radical surgery has been undertaken. Clinical stage at presentation was IB (58 patients) and IIA (12 patients). Thirty-five patients (50%) had squamous carcinoma, 23 (33%) had adenosquamous carcinoma, 9 (13%) had adenocarcinoma and 3 (4%) had an undifferentiated neoplasm. The reasons for further treatment were: (i) pelvic lymph node metastases (PLNM), 35 (50%); (ii) inadequate central clearance (ICC), 13 (18%); (iii) recurrent disease (RD), 17 (24%); (iv) others, 5 (8%) cases. Sixty-seven patients had radiotherapy, one of whom also received adjuvant chemotherapy, three patients had chemotherapy alone, and 12 patients received chemotherapy for recurrence following radiotherapy. The 5-year survival in the above referral groups were: (i) 66%; (ii) 62%; (iii) 12%. The site of relapse following treatment was primarily pelvic in groups 2 (ICC) and 3 (RD) and extrapelvic in group 1 (PLNM). Of the histologic parameters studied the only factor of statistical significance in predicting outcome in this group who are recognized to have a generally poor prognosis was the presence of parametrial extension (P = 0.0066). Six cases (9%) developed complications following therapy, lymphoedema being the most common (66%).
Affiliation:
Department of Radiotherapy and Oncology, Christie Hospital, Manchester; Departments of Reproductive Pathology and Obstetrics and Gynaecology, St Mary's Hospital, Manchester; Department of Obstetrics and Gynaecology, Royal Victoria Hospital, Blackpool, UK.
Citation:
Carcinoma of the cervix: an analysis of prognostic factors, treatment and patterns of failure following Wertheims hysterectomy. 1992, 2 (6):323-327 Int J Gynecol Cancer
Journal:
International Journal of Gynecological Cancer
Issue Date:
Nov-1992
URI:
http://hdl.handle.net/10541/109652
DOI:
10.1046/j.1525-1438.1992.02060323.x
PubMed ID:
11576277
Type:
Article
Language:
en
ISSN:
1525-1438
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorLogue, John Pen
dc.contributor.authorHale, R Jen
dc.contributor.authorWilcox, F Len
dc.contributor.authorHunter, Robin Den
dc.contributor.authorBuckley, C Hen
dc.contributor.authorTindall, V Ren
dc.date.accessioned2010-08-16T15:04:15Z-
dc.date.available2010-08-16T15:04:15Z-
dc.date.issued1992-11-
dc.identifier.citationCarcinoma of the cervix: an analysis of prognostic factors, treatment and patterns of failure following Wertheims hysterectomy. 1992, 2 (6):323-327 Int J Gynecol Canceren
dc.identifier.issn1525-1438-
dc.identifier.pmid11576277-
dc.identifier.doi10.1046/j.1525-1438.1992.02060323.x-
dc.identifier.urihttp://hdl.handle.net/10541/109652-
dc.description.abstractA clinicopathologic analysis of 70 patients treated by radiotherapy and/or chemotherapy following primary radical surgery has been undertaken. Clinical stage at presentation was IB (58 patients) and IIA (12 patients). Thirty-five patients (50%) had squamous carcinoma, 23 (33%) had adenosquamous carcinoma, 9 (13%) had adenocarcinoma and 3 (4%) had an undifferentiated neoplasm. The reasons for further treatment were: (i) pelvic lymph node metastases (PLNM), 35 (50%); (ii) inadequate central clearance (ICC), 13 (18%); (iii) recurrent disease (RD), 17 (24%); (iv) others, 5 (8%) cases. Sixty-seven patients had radiotherapy, one of whom also received adjuvant chemotherapy, three patients had chemotherapy alone, and 12 patients received chemotherapy for recurrence following radiotherapy. The 5-year survival in the above referral groups were: (i) 66%; (ii) 62%; (iii) 12%. The site of relapse following treatment was primarily pelvic in groups 2 (ICC) and 3 (RD) and extrapelvic in group 1 (PLNM). Of the histologic parameters studied the only factor of statistical significance in predicting outcome in this group who are recognized to have a generally poor prognosis was the presence of parametrial extension (P = 0.0066). Six cases (9%) developed complications following therapy, lymphoedema being the most common (66%).en
dc.languageENG-
dc.language.isoenen
dc.subjectCarcinomaen
dc.subjectCervixen
dc.subjectRadiotherapyen
dc.subjectWertheimsen
dc.titleCarcinoma of the cervix: an analysis of prognostic factors, treatment and patterns of failure following Wertheims hysterectomy.en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiotherapy and Oncology, Christie Hospital, Manchester; Departments of Reproductive Pathology and Obstetrics and Gynaecology, St Mary's Hospital, Manchester; Department of Obstetrics and Gynaecology, Royal Victoria Hospital, Blackpool, UK.en
dc.identifier.journalInternational Journal of Gynecological Canceren

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