2.50
Hdl Handle:
http://hdl.handle.net/10541/109644
Title:
Endocrine deficit after fractionated total body irradiation.
Authors:
Ogilvy-Stuart, Amanda L; Clark, D J; Wallace, W Hamish B; Gibson, B E; Stevens, R F; Shalet, Stephen M; Donaldson, M D
Abstract:
Endocrine function was assessed in 31 children (17 boys) after fractionated total body irradiation used in the preparative regimen for bone marrow transplantation. Endocrine dysfunction was present in 25 children. Fifteen of 29 had growth hormone insufficiency 0.9-4.9 years after total body irradiation, yet only three of the 15 had received previous cranial irradiation. Five of 30 had thyroid dysfunction: two with a low thyroxine and raised thyroid stimulating hormone (TSH) concentration and three with a raised TSH and normal thyroxine concentration. Thus the incidence of thyroid dysfunction (16%) is much lower than that reported after single fraction total body irradiation (39-59%). In only two children were abnormalities of the hypothalamic-pituitary-adrenal axis demonstrated. The majority of pubertal children assessed (n = 15) showed evidence of gonadal damage. All the pubertal girls (n = 5) had ovarian failure, although there was evidence of recovery of ovarian function in one girl. All seven boys in late puberty showed evidence of damage to the germinal epithelium, and two of three in early puberty had raised follicle stimulating hormone concentrations. Despite the use of a fractionated total body irradiation regimen, endocrine morbidity is substantial and children undergoing such procedures will require long term endocrine review and management.
Affiliation:
Royal Hospital for Sick Children, Yorkhill, Glasgow.
Citation:
Endocrine deficit after fractionated total body irradiation. 1992, 67 (9):1107-10 Arch Dis Child
Journal:
Archives of Disease in Childhood
Issue Date:
Sep-1992
URI:
http://hdl.handle.net/10541/109644
DOI:
10.1136/adc.67.9.1107
PubMed ID:
1417055
Type:
Article
Language:
en
ISSN:
1468-2044
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorOgilvy-Stuart, Amanda Len
dc.contributor.authorClark, D Jen
dc.contributor.authorWallace, W Hamish Ben
dc.contributor.authorGibson, B Een
dc.contributor.authorStevens, R Fen
dc.contributor.authorShalet, Stephen Men
dc.contributor.authorDonaldson, M Den
dc.date.accessioned2010-08-16T13:58:45Z-
dc.date.available2010-08-16T13:58:45Z-
dc.date.issued1992-09-
dc.identifier.citationEndocrine deficit after fractionated total body irradiation. 1992, 67 (9):1107-10 Arch Dis Childen
dc.identifier.issn1468-2044-
dc.identifier.pmid1417055-
dc.identifier.doi10.1136/adc.67.9.1107-
dc.identifier.urihttp://hdl.handle.net/10541/109644-
dc.description.abstractEndocrine function was assessed in 31 children (17 boys) after fractionated total body irradiation used in the preparative regimen for bone marrow transplantation. Endocrine dysfunction was present in 25 children. Fifteen of 29 had growth hormone insufficiency 0.9-4.9 years after total body irradiation, yet only three of the 15 had received previous cranial irradiation. Five of 30 had thyroid dysfunction: two with a low thyroxine and raised thyroid stimulating hormone (TSH) concentration and three with a raised TSH and normal thyroxine concentration. Thus the incidence of thyroid dysfunction (16%) is much lower than that reported after single fraction total body irradiation (39-59%). In only two children were abnormalities of the hypothalamic-pituitary-adrenal axis demonstrated. The majority of pubertal children assessed (n = 15) showed evidence of gonadal damage. All the pubertal girls (n = 5) had ovarian failure, although there was evidence of recovery of ovarian function in one girl. All seven boys in late puberty showed evidence of damage to the germinal epithelium, and two of three in early puberty had raised follicle stimulating hormone concentrations. Despite the use of a fractionated total body irradiation regimen, endocrine morbidity is substantial and children undergoing such procedures will require long term endocrine review and management.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshAdrenal Insufficiency-
dc.subject.meshBone Marrow Transplantation-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEndocrine System Diseases-
dc.subject.meshFemale-
dc.subject.meshGonads-
dc.subject.meshGrowth Hormone-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshProlactin-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshThyroid Diseases-
dc.subject.meshWhole-Body Irradiation-
dc.titleEndocrine deficit after fractionated total body irradiation.en
dc.typeArticleen
dc.contributor.departmentRoyal Hospital for Sick Children, Yorkhill, Glasgow.en
dc.identifier.journalArchives of Disease in Childhooden

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