Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109630
Title:
Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents.
Authors:
Harrison, Christine J
Abstract:
Six cases of acute myeloid leukemia (AML) with translocations involving 12p are described. The patients were one child age 7 yrs and five adults with an age range of 20-66 yrs (median 46 yrs). In two patients AML followed treatment for acute lymphoblastic leukemia (ALL), in one case after 11 years disease-free survival. Of the remaining four patients, two had been occupationally exposed to possible mutagens and three had a previous myelodysplastic phase. Two patients achieved complete remission; survival for the six cases was between 1 and 24 months (median 6.5 months). The breakpoints in 12p occurred in p11, p12, and p13, indicating that several sites are important in these rearrangements, and it is suggested that t(12;17)(p11;q11) is a new nonrandom abnormality in AML.
Affiliation:
UKCCG, Dept. of Haematology, The Royal Free Hospital and School of Medicine, Pond St,. London NW3 2QG, UK.
Citation:
Translocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG). 1992, 5 (3):252-4 Genes Chromosomes Cancer
Journal:
Genes, Chromosomes & Cancer
Issue Date:
Oct-1992
URI:
http://hdl.handle.net/10541/109630
DOI:
10.1002/gcc.2870050313
PubMed ID:
1384679
Type:
Article
Language:
en
ISSN:
1045-2257
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHarrison, Christine Jen
dc.date.accessioned2010-08-16T14:08:45Z-
dc.date.available2010-08-16T14:08:45Z-
dc.date.issued1992-10-
dc.identifier.citationTranslocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents. United Kingdom Cancer Cytogenetics Group (UKCCG). 1992, 5 (3):252-4 Genes Chromosomes Canceren
dc.identifier.issn1045-2257-
dc.identifier.pmid1384679-
dc.identifier.doi10.1002/gcc.2870050313-
dc.identifier.urihttp://hdl.handle.net/10541/109630-
dc.description.abstractSix cases of acute myeloid leukemia (AML) with translocations involving 12p are described. The patients were one child age 7 yrs and five adults with an age range of 20-66 yrs (median 46 yrs). In two patients AML followed treatment for acute lymphoblastic leukemia (ALL), in one case after 11 years disease-free survival. Of the remaining four patients, two had been occupationally exposed to possible mutagens and three had a previous myelodysplastic phase. Two patients achieved complete remission; survival for the six cases was between 1 and 24 months (median 6.5 months). The breakpoints in 12p occurred in p11, p12, and p13, indicating that several sites are important in these rearrangements, and it is suggested that t(12;17)(p11;q11) is a new nonrandom abnormality in AML.en
dc.language.isoenen
dc.subjectMyeloid Leukaemiaen
dc.subjectSecond Primary Canceren
dc.subject.meshAcute Disease-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshChild-
dc.subject.meshChromosomes, Human, Pair 12-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLeukemia, Myeloid-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMutagens-
dc.subject.meshMyelodysplastic Syndromes-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshTranslocation, Genetic-
dc.titleTranslocations involving 12p in acute myeloid leukemia: association with prior myelodysplasia and exposure to mutagenic agents.en
dc.typeArticleen
dc.contributor.departmentUKCCG, Dept. of Haematology, The Royal Free Hospital and School of Medicine, Pond St,. London NW3 2QG, UK.en
dc.identifier.journalGenes, Chromosomes & Canceren

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