Translocations involving 9p and/or 12p in acute lymphoblastic leukemia. United Kingdom Cancer Cytogenetics Group (UKCCG).

2.50
Hdl Handle:
http://hdl.handle.net/10541/109629
Title:
Translocations involving 9p and/or 12p in acute lymphoblastic leukemia. United Kingdom Cancer Cytogenetics Group (UKCCG).
Authors:
Harrison, Christine J
Abstract:
Fifteen cases of acute lymphoblastic leukemia (ALL) with translocations involving 9p and/or 12p are described. Four children, three males and one female, age range 1-8 yrs, had translocations involving 9p but not 12p. Of these, three had B-lineage ALL and one had biphenotypic T-ALL/acute myeloid leukemia. Six patients, three males and three females, age range 1-49 yrs, had translocations involving 12p but not 9p. Five had B-lineage ALL and one had T-ALL. One patient had dic(7;12)(p11;p11), confirming that this previously reported translocation is nonrandom in ALL. One patient had t(2;12)(q14;p13), and it is suggested that this may also be a new nonrandom abnormality. Five patients, four males and one female, age range 11-21 yrs, had common ALL and dic(9;12). The dic(9;12) appears to confer a better prognosis than do other translocations involving 9p or 12p.
Affiliation:
UKCCG, Dept. of Haematology, The Royal Free Hospital and School of Medicine, Pond St., London NW3 2QG, UK.
Citation:
Translocations involving 9p and/or 12p in acute lymphoblastic leukemia. United Kingdom Cancer Cytogenetics Group (UKCCG). 1992, 5 (3):255-9 Genes Chromosomes Cancer
Journal:
Genes, Chromosomes & Cancer
Issue Date:
Oct-1992
URI:
http://hdl.handle.net/10541/109629
DOI:
10.1002/gcc.2870050314
PubMed ID:
1384680
Type:
Article
Language:
en
ISSN:
1045-2257
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHarrison, Christine Jen
dc.date.accessioned2010-08-16T14:06:07Z-
dc.date.available2010-08-16T14:06:07Z-
dc.date.issued1992-10-
dc.identifier.citationTranslocations involving 9p and/or 12p in acute lymphoblastic leukemia. United Kingdom Cancer Cytogenetics Group (UKCCG). 1992, 5 (3):255-9 Genes Chromosomes Canceren
dc.identifier.issn1045-2257-
dc.identifier.pmid1384680-
dc.identifier.doi10.1002/gcc.2870050314-
dc.identifier.urihttp://hdl.handle.net/10541/109629-
dc.description.abstractFifteen cases of acute lymphoblastic leukemia (ALL) with translocations involving 9p and/or 12p are described. Four children, three males and one female, age range 1-8 yrs, had translocations involving 9p but not 12p. Of these, three had B-lineage ALL and one had biphenotypic T-ALL/acute myeloid leukemia. Six patients, three males and three females, age range 1-49 yrs, had translocations involving 12p but not 9p. Five had B-lineage ALL and one had T-ALL. One patient had dic(7;12)(p11;p11), confirming that this previously reported translocation is nonrandom in ALL. One patient had t(2;12)(q14;p13), and it is suggested that this may also be a new nonrandom abnormality. Five patients, four males and one female, age range 11-21 yrs, had common ALL and dic(9;12). The dic(9;12) appears to confer a better prognosis than do other translocations involving 9p or 12p.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshChromosomes, Human, Pair 12-
dc.subject.meshChromosomes, Human, Pair 9-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshTranslocation, Genetic-
dc.titleTranslocations involving 9p and/or 12p in acute lymphoblastic leukemia. United Kingdom Cancer Cytogenetics Group (UKCCG).en
dc.typeArticleen
dc.contributor.departmentUKCCG, Dept. of Haematology, The Royal Free Hospital and School of Medicine, Pond St., London NW3 2QG, UK.en
dc.identifier.journalGenes, Chromosomes & Canceren

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