Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.

2.50
Hdl Handle:
http://hdl.handle.net/10541/109500
Title:
Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.
Authors:
Carrington, Bernadette M; Thomas, N B; Johnson, Richard J
Abstract:
A retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%).
Affiliation:
Department of Diagnostic Radiology, Christie Hospital and Holt Radium Institute, Manchester, U.K.
Citation:
Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures., 14 (1):13-7 Eur J Radiol
Journal:
European Journal of Radiology
Issue Date:
1992
URI:
http://hdl.handle.net/10541/109500
DOI:
10.1016/0720-048X(92)90054-D
PubMed ID:
1563397
Type:
Article
Language:
en
ISSN:
0720-048X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorCarrington, Bernadette Men
dc.contributor.authorThomas, N Ben
dc.contributor.authorJohnson, Richard Jen
dc.date.accessioned2010-08-11T16:26:03Z-
dc.date.available2010-08-11T16:26:03Z-
dc.date.issued1992-
dc.identifier.citationSelective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures., 14 (1):13-7 Eur J Radiolen
dc.identifier.issn0720-048X-
dc.identifier.pmid1563397-
dc.identifier.doi10.1016/0720-048X(92)90054-D-
dc.identifier.urihttp://hdl.handle.net/10541/109500-
dc.description.abstractA retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%).en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAngiography-
dc.subject.meshCatheterization-
dc.subject.meshCeliac Artery-
dc.subject.meshContrast Media-
dc.subject.meshEmbolism-
dc.subject.meshEquipment Design-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHumans-
dc.subject.meshInterleukin-2-
dc.subject.meshMale-
dc.subject.meshMelanoma-
dc.subject.meshMiddle Aged-
dc.subject.meshPain-
dc.subject.meshPunctures-
dc.subject.meshRetrospective Studies-
dc.subject.meshSplenic Artery-
dc.subject.meshThrombosis-
dc.titleSelective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.en
dc.typeArticleen
dc.contributor.departmentDepartment of Diagnostic Radiology, Christie Hospital and Holt Radium Institute, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Radiologyen

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