2.50
Hdl Handle:
http://hdl.handle.net/10541/109499
Title:
Cervical carcinoma: a hazard model in early stage disease.
Authors:
Hale, R J; Ryder, W David J; Wilcox, F L; Buckley, C H; Tindall, V R
Abstract:
The 235 patients with stage IB/IIA cervical carcinoma treated by Wertheim's hysterectomy, as a primary procedure, at St Mary's Hospital, Manchester between 1975 and 1989 inclusive, form the basis of this study. Using Cox's regression model, four variables were shown to have independent prognostic significance. These were: (1) lymphatic permeation (adjacent to the tumor); (2) tumor volume; (3) being pregnant at diagnosis and (4) lymph node metastases. A heuristic model was formulated which was based upon these four factors and by using this information it was possible to separate the patients into four distinct prognostic groups. It is suggested that this model may prove useful in identifying those patients at a higher risk of dying of disease and who would benefit from early adjuvant systemic therapy.
Affiliation:
Department of Reproductive Pathology and the University Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester Department of Medical Statistics, Christie Hospital and Holt Radium Institute, Manchester Department of Obstetrics and Gynaecology, Royal Victoria Hospital, Blackpool.
Citation:
Cervical carcinoma: a hazard model in early stage disease. 1992, 2 (2):79-82 Int J Gynecol Cancer
Journal:
International Journal of Gynecological Cancer
Issue Date:
Mar-1992
URI:
http://hdl.handle.net/10541/109499
DOI:
10.1046/j.1525-1438.1992.02020079.x
PubMed ID:
11576240
Type:
Article
Language:
en
ISSN:
1525-1438
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHale, R Jen
dc.contributor.authorRyder, W David Jen
dc.contributor.authorWilcox, F Len
dc.contributor.authorBuckley, C Hen
dc.contributor.authorTindall, V Ren
dc.date.accessioned2010-08-11T16:24:05Z-
dc.date.available2010-08-11T16:24:05Z-
dc.date.issued1992-03-
dc.identifier.citationCervical carcinoma: a hazard model in early stage disease. 1992, 2 (2):79-82 Int J Gynecol Canceren
dc.identifier.issn1525-1438-
dc.identifier.pmid11576240-
dc.identifier.doi10.1046/j.1525-1438.1992.02020079.x-
dc.identifier.urihttp://hdl.handle.net/10541/109499-
dc.description.abstractThe 235 patients with stage IB/IIA cervical carcinoma treated by Wertheim's hysterectomy, as a primary procedure, at St Mary's Hospital, Manchester between 1975 and 1989 inclusive, form the basis of this study. Using Cox's regression model, four variables were shown to have independent prognostic significance. These were: (1) lymphatic permeation (adjacent to the tumor); (2) tumor volume; (3) being pregnant at diagnosis and (4) lymph node metastases. A heuristic model was formulated which was based upon these four factors and by using this information it was possible to separate the patients into four distinct prognostic groups. It is suggested that this model may prove useful in identifying those patients at a higher risk of dying of disease and who would benefit from early adjuvant systemic therapy.en
dc.languageENG-
dc.language.isoenen
dc.subjectCervical Carcinomaen
dc.subjectHeuristic Modelen
dc.subjectPrognostic Factorsen
dc.titleCervical carcinoma: a hazard model in early stage disease.en
dc.typeArticleen
dc.contributor.departmentDepartment of Reproductive Pathology and the University Department of Obstetrics and Gynaecology, St Mary's Hospital, Manchester Department of Medical Statistics, Christie Hospital and Holt Radium Institute, Manchester Department of Obstetrics and Gynaecology, Royal Victoria Hospital, Blackpool.en
dc.identifier.journalInternational Journal of Gynecological Canceren
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